摘要
目的探讨含Sushi重复蛋白X连锁2(Sushi repeat containing protein,X-linked 2,SRPX2)在非小细胞肺癌(nonsmall cell lung cancer,NSCLC)组织中的表达及其临床意义。方法采用免疫组织化学方检测93例NSCLC组织和23例癌旁正常组织中SRPX2的表达,并分析与NSCLC患者临床病理特征及预后的关系。结果 SRPX2在NSCLC中的表达率为52.7%(49/93),显著高于癌旁正常组织中的表达率0%(0/26),在Ⅲ期中的阳性表达率明显高于Ⅰ、Ⅱ期,有淋巴结转移组织中的阳性表达率明显高于无淋巴结转移组织,而与患者性别、年龄、有无吸烟、组织学类型及分化程度无关。Kaplan-meier生存曲线显示,SRPX2阳性表达的患者生存率明显低于表达阴性者。结论 SRPX2在NSCLC组织中阳性表达,对肿瘤细胞的浸润和转移起促进作用,阳性表达患者生存率低。
Objective To investigate the expression and clinical significance of Sushi repeat containing protein,X-linked2(SRPX2)in non-small cell lung cancer(NSCLC).Methods Immunohistochemistry was applied to detect the expression of SRPX2in the tissues of93NSCLC cases and23cases of adjacent normal tissues.The relationship between the expression of SRPX2and the clinicopathologic characteristics and prognosis of NSCLC was analyzed.Results The positive rate of SRPX2expression in NSCLC tissues was52.7%(49/93),which was significantly higher than in adjacent normal tissues(0/26).It increased significantly in stageⅢthan that in stageⅠandⅡ.The rate in lymph node metastasis tissues was also significantly higher than that in non-lymph node metastasis tissues.However,SRPX2expression was not associated with sex,age,smoking,differentiation and histological classification.Kaplanmeier survival analysis showed significantly lower survival rate in patients with positive SRPX2expression than those with negative expression.Conclusion The expression of SRPX2in NSCLC tissues may promote tumor cell invasion and metastasis,therefore reduce survival rate.
作者
李娟
王开金
程序
Li Juan;Wang Kaijin;Cheng Xu(Department of Respiration Medicine, Jiangjin District Central Hospital, Jiangjin Institute for respiratory diseases, Chongqing 402260, China;Department of Pathology, Zigong fourth People’s Hospital, Zigong 643000, China)
出处
《中国组织化学与细胞化学杂志》
CAS
CSCD
2018年第1期53-56,共4页
Chinese Journal of Histochemistry and Cytochemistry
基金
重庆市医疗特色专科项目
重庆市区域重点学科建设(zdxk201701)
