摘要
光学分子影像以其非侵袭性、实时、分辨率高等特点,被越来越多地应用于生物医学研究领域。近红外荧光(near-infrared fluorescence,NIRF)染料作为重要的光学分子影像探针,由于其波长被组织吸收少,组织穿透力强,正在逐步应用于肿瘤的早期诊断。人们通过偶联肿瘤靶向配体、纳米修饰以及采用多模态近红外荧光成像等方式,开发出一批具有临床应用潜能的NIRF染料,显著提高了该类染料用于肿瘤诊断的特异性和敏感性。本文就NIRF染料在肿瘤诊断中的应用进行综述。
Optical molecular imaging is more and more widely used in the field of biomedical sciences due to its advantageous properties such as non-invasive,real-time and high resolution.As a kind of important optical molecular imaging probe,the near-infrared fluorescent(NIRF)dyes exhibit less tissue absorption and strong tissue penetration,and has been gradually applied to the early diagnosis of tumors.Researchers have developed a number of NIRF dyes with high potential for clinical application by conjugating tumor-targeting ligands,nano-modifications and multimodal NIRF imaging,and have significantly improved the specificity and sensitivity of these NIRF dyes in tumor diagnosis.In this paper we provide a review on the application of NIRF dyes in tumor diagnosis.
作者
赵勇
王浩
师长宏
ZHAO Yong;WANG Hao;SHI Changhong(Laboratory Animal Center,the Fourth Military Medical University,Xi’an 710032,China)
出处
《中国比较医学杂志》
CAS
北大核心
2018年第3期98-102,共5页
Chinese Journal of Comparative Medicine
基金
国家自然科学基金(编号:31572340
31772546)
军队实验动物专项(编号:SYDW2016-006)
关键词
近红外荧光染料
肿瘤
诊断
纳米修饰
多模态成像
near-infrared fluorescent dye
NIRF dye
tumors
diagnosis
nano-modifications
multimodal imaging
