摘要
目的探讨糖化血红蛋白(HbA1c)、糖化血清蛋白(GSP)、性激素结合球蛋白(SHBG)、三酰甘油(TG)、游离脂肪酸(FFA)在妊娠期糖尿病(GDM)诊断中的临床价值。方法选取2015年2月至2016年8月收治的GDM患者103例和健康孕妇98例分别作为GDM组和对照组,比较两组HbA1c、GSP、SHBG、TG、FFA水平和阳性检出率,并对各指标诊断效能进行分析。结果 GDM组HbA1c、GSP、TG、FFA水平明显高于对照组,而SHBG水平明显低于对照组,差异有统计学意义(P<0.05);GDM组HbA1c、GSP、SHBG、TG、FFA阳性率明显高于对照组,差异有统计学意义(P<0.05);HbA1c、GSP、SHBG、TG、FFA联合诊断GDM的特异度、灵敏度和阳性预测值均明显高于各单项指标,差异有统计学意义(P<0.05)。结论 HbA1c、GSP、SHBG、TG、FFA联合诊断GDM更为准确,具有重要临床价值,可作为GDM辅助诊断指标。
Objective To investigate the clinical value of glycosylated hemoglobin(HbA1c),glycosylated serum protein(GSP),sex hormone binding globulin(SHBG),three acylglycerol(TG),free fatty acid(FFA)in diagnosing gestational diabetes mellitus(GDM).Methods103cases of GDM patients and98cases of healthy pregnant women from February2015to August2016were selected as the GDM group and control group.The positive detection rates and levels of HbA1c,GSP,SHBG,TG and FFA were compared between the two groups.Moreover the diagnostic efficiency of various indicators was analyzed.Results The levels of HbA1c,GSP,TG and FFA in the GDM group were significantly higher than those in the control group,while the SHBG level was significantly lower than that in the control group,the difference was statistically significant(P<0.05);the positive rates of HbA1c,GSP,SHBG,TG and FFA in the GDM group were significantly higher than those in the control group,the difference was statistically significant(P<0.05);the specificity,sensitivity and positive prediction value of HbA1c,GSP,SHBG,TG and FFA for jointly diagnosing GDM were significantly higher than those of single indicator,the difference was statistically significant(P<0.05).Conclusion Detecting HbA1c,NGSP,SHBG,TG and FFA is more accurate for jointly diagnosing GDM,has an important diagnostic value,and can serve as the assisted diagnostic indicators.
作者
吴寿荣
黄和明
马炜锋
WU Shourong;HUANG Heming;MA Weifeng(Department of Clinical Laboratory,Longgang District Fifth People′s Hospital,Shenzhen,Gaungdong 518111,China;Department of Clinical Laboratory,Longgang District Maternity and Child Healthcare Hospital,Shenzhen,Gaungdong 518172,China)
出处
《国际检验医学杂志》
CAS
2018年第6期678-680,共3页
International Journal of Laboratory Medicine
基金
深圳市龙岗区科技发展资金医疗卫生项目(YS2013174)
关键词
妊娠期糖尿病
糖化血红蛋白
糖化血清蛋白
性激素结合球蛋白
gestational diabetes mellitus
glycosylated hemoglobin
glycosylated serum protein
sex hormone binding globulin
