摘要
目的:评价川芎平喘合剂治疗慢性阻塞性肺疾病(COPD)的临床疗效。方法:将COPD患者144例按随机数字表法分为对照组和治疗组各72例。对照组给予西医常规联合安慰剂治疗,治疗组在西医常规治疗基础上给予川芎平喘合剂,疗程21天。观察治疗前后2组患者COPD评估测试(CAT)评分及中医证候积分等指标。结果:治疗后治疗组喘息、胸闷、气短积分及中医证候积分总分均低于对照组(P<0.05);治疗组患者咳嗽、胸闷、气喘等CAT评分较对照组降低(P<0.05),做事、外出信心、睡眠、精力等CAT评分低于对照组,但差异无统计学意义(P>0.05);2组患者动脉血氧分压(Pa0_2)、二氧化碳分压(PaC0_2)均较治疗前改善(P<0.05);治疗组Pa0_2、PaC0_2改善程度优于对照组(P<0.05)。治疗后2组第1秒用力呼气容积占预计值百分比(FEV_1%pred)水平高于治疗前,差异具有统计学意义(P<0.05),治疗组FEV_1%pred水平高于对照组,但差异无统计学意义(P>0.05)。结论:川芎平喘合剂结合西医常规治疗COPD可进一步改善患者咳嗽、咯痰、胸闷、呼吸困难等临床症状和生活质量。
Objective:To assess clinical effects of ChuanXiong PingChuan mixture in treating chronic obstructive pulmonary disease(COPD).Methods:All 144 COPD patients were divided into the control group and the treatment group according to random number table method,72 cases each group.The control group accepted routine treatment of western medicine and placebo,and the treatment group took ChuanXiong PingChuan mixture on the foundation of routine treatment of western medicine,for 21 days.CAT scales and TCM syndrome scales of both groups were observed before and after treating.Results:After treating,the treatment group was lower than the control group in the scales of panting,choking sensation in chest,breathing hard and TCMsyndrome scales(P<0.05);the decrease of CAT scales including cough,choking sensation in chest and panting in the treatment group were more obvious compared with the control group(P<0.05),lower than the control group in CAT scales such as working,out-of-office,confidence,sleep,energy and others,while the difference had no statistical meaning(P>0.05);PaO2 and PaCO2 of both groups improved compared with before treating(P<0.05);the improvements of PaO2 and PaCO2 in the treatment group were superior to these of the control group(P<0.05).After treating,the levels of FEV1%pred of both groups were higher than these before treating,and the difference had statistical meaning(P<0.05),the treatment group was higher than the control group in the levels of FEV1%pred,but the difference had no statistical meaning(P>0.05).Conclusion:ChuanXiong PingChuan mixture combined with routine treatment of western medicine in treating COPD could improve clinical symptoms including cough,sputum,choking sensation in chest,dyspnea,and others,as well as quality of life further.
作者
郭晓燕
腾飞
张惠勇
GUO Xiaoyan;TENG Fei;ZHANG Huiyong(Department of Pulmonary Disease,Longhua Hospital Shanghai University of TCM,Shanghai 200032,China)
出处
《西部中医药》
2018年第1期1-4,共4页
Western Journal of Traditional Chinese Medicine
基金
国家青年自然基金项目(编号81202922)
上海市科委医学与农业领域项目(编号13401901705)
关键词
慢性阻塞性肺疾病
CAT评分
川芎平喘合剂
chronic obstructive pulmonary disease
CAT scales
ChuanXiong PingChuan mixture
