摘要
黄芪含有皂苷类、黄酮类、多糖类、微量元素等多种药效成分。黄芪多糖(APS)、黄芪甲苷(AST)、环黄芪醇(CAG)、黄芪总皂苷(TSA)、黄芪黄酮(TFA)、黄芪水提物(WEA)等药效成分干预肺纤维化(PF)相关实验研究是黄芪研究的热点之一。大量国内外研究从调节多种信号传导通路,调节细胞分化关键因子及基因的表达,调节氧化应激(OS)反应,调节炎症反应,改善组织形态学,端粒酶激活作用,调节细胞外基质(ECM)及基质金属蛋白酶等多个方面,试图揭示黄芪及其药效成分干预PF的作用机制。但多数研究均探讨了单一因子或信号通路,而对于多种作用机制的网络调控关系缺少关注。基于多层次、多角度及系统生物学的思路研究黄芪及其药效成分干预PF的作用机制及治疗靶标应成为后续研究的重点。
Astragali Radix had abundant medicinal compositions of saponins,flavonoids,polysaccharides and trace elements.A present hotspot was experiment mechanism study of Astragali Radix and its medicinal compositions on pulmonary fibrosis(PF),including astragalus polysaccharide(APS),astragalosideⅣ(AST),cycloastragenol(CAG),total saponins of astragalus(TSA),total flavonoids of astragalus(TFA),and watery extract of astragalus(WEA).A large number of domestic and foreign studies focused on revealling the intervention mechanism of Astragali Radix and its medicinal compositions on PF from the perspective of regulating signal transduction pathways,regulating key factors and gene expression of cell differentiation,regulating oxidative stress(OS)response,regulating inflammatory response,improving histomorphology,activating telomerase,and regulating extracellular matrix(ECM)and matrixmetalloproteinases.However,most studies of them only investigated the single factor or signal pathway,and lacked of attention to network regulation relationship of multiple mechanisms.Based on multi-level,multi-angle and systematic biology,the study of intervention mechanism and treatment target of Astragali Radix and its medicinal compositions on PF should be the research emphasis in follow up study.
作者
顾志荣
李芳
葛斌
GU Zhi-rong;LI Fang;GE Bin(Department of Pharmacy,Gansu Provincial People's Hospital;Gansu University of Traditional Chinese Medicine,Lanzhou 730000,China)
出处
《天然产物研究与开发》
CAS
CSCD
北大核心
2018年第1期161-167,共7页
Natural Product Research and Development
基金
甘肃省人民医院青年科研项目(16GSSY7-2)
国家自然科学基金(81260597)
甘肃省中医药管理局科研项目(GZK-2015-45)
关键词
黄芪
药效成分
肺纤维化
作用机制
实验研究
Astragali Radix
medicinal compositions
pulmonary fibrosis
mechanism of action
experimental study
