摘要
采用HPLC方法建立独一味药材及独一味胶囊的特征指纹图谱,运用相似度评价药材质量;并结合化学计量学对独一味药材进行分类,以相对保留时间对独一味药材和独一味胶囊进行成分一致性评价。结果显示,独一味药材含共有峰23个,独一味胶囊含共有峰24个;10批独一味药材的相似度均大于0.85,可见药材来源较为单一;同时结合化学计量学中聚类分析和主成分分析对10批药材进行分类,可将其分为4类,且分类结果一致,可见以该法评价独一味药材可行;并对以同一HPLC特征图谱方法建立的独一味药材及独一味胶囊特征图谱进行比较,可知独一味胶囊很好的保留了独一味药材的诸多药效成分。
The fingerprint of Lamiophlomis rotata(Benth.)Kudo and its capsule was established and its equality was evaluated by similarity.There was 23 common peaks of L.rotata and 24 common peaks of its capsule.Similarity of 10 batches of L.rotata was more than 0.85.Ten batches of L.rotata was classified to 4 kinds by chemometrics and the results were same so that it was workable.By comparing with fingerprint of L.rotata and its capsule which was analyzed by the same methods,the results showed most of the medicinal composition of L.rotata were reserved in its capsule.
作者
张燕琴
潘伟男
姚蓉
阎敏
陈锋
ZHANG Yan-qin;PAN Wei-nan;YAO Rong;YAN Min;CHEN Feng(Hunan Food and Drug Vocational College,Changsha 410208,China;Xiangya Hospital Central South University,Changsha 410008,China)
出处
《天然产物研究与开发》
CAS
CSCD
北大核心
2018年第2期251-256,共6页
Natural Product Research and Development
基金
湖南中医药管理局科技计划(201499)
关键词
独一味药材
独一味胶囊
特征图谱
化学计量学
一致性
Lamiophlomis rotata
capsule of Lamiophlomis rotata
fingerprint
chemometrics
consistency
