摘要
香豆素类化合物是自然界非常重要的一大类天然化合物,在医学方面应用广泛,具有抗癌、抗炎、抗凝血及抗菌等多方面活性,香豆素类化合物的农用生物活性也逐渐被重视。本文综述了近年来香豆素类化合物在抑菌生物活性方面的研究成果,医学上主要对象是金黄色葡萄球菌、大肠杆菌、铜绿假单胞菌、β-溶血性链球菌、流感嗜血杆菌、霍乱弧菌等;在农用抑菌方面则集中在青枯雷尔氏菌、辣椒疫霉病菌、白粉病菌、番茄灰霉病菌、小麦赤霉病菌等。进一步,列举了23种潜在的香豆素类化合物及其抑菌活性,简要分析了香豆素类化合物抑菌活性的构效关系和作用机理。香豆素类化合物母核具有多个取代位点,可作为一种先导化合物,合成更加有效的香豆素类化合物衍生物,具有广阔的应用价值。
Coumarins are naturally derived compounds fused benzene andα-pyrone rings which are found in large range of plant sources.Recently,several studies have been conducted on the biological activity of coumarins,such as anticancers,anti-inflammatory,anticoagulants,antibacterial and antifungals.In this study,the advances on the antibacterial activity of coumarins were summarized.The main target in medicine is Staphylococcus aureus,Escherichia coli,Pseudomonas aeruginosa,β-hemolytic streptococcus,Haemophilus infuenzae and Vibrio cholera,etc.,in the agricultural areas are concentrated in Ralstonia solanacearum,Phytophthora capsici,Powdery mildew,Botrytis cinerea and Fusarium graminearum,etc.Indeed,the structure-activity relationship and mechanism action of coumarins were analyzed.Coumarins have multiple substitution sites and can used as a kind of lead compound to synthesize more effective coumarin derivatives with widely application values.
作者
杨亮
姚晓远
丁伟
YANG Liang;YAO Xiao-yuan;DING Wei(Laboratory of Natural Products Pesticides,College of Plant Protection,Southwest University,Chongqing 400716,China)
出处
《天然产物研究与开发》
CAS
CSCD
北大核心
2018年第2期332-338,共7页
Natural Product Research and Development
基金
国家自然科学基金(31572041)
中央高校基本业务费项目(XDJK2017D166)
关键词
香豆素类化合物
抑菌活性
构效关系
作用机理
coumarins
antibacterial activity
structure-activity relationship
mechanism action
