摘要
目的:探讨进展期脑卒中病人颈动脉斑块积分与生化指标的相关性,分析斑块易损性的危险因素,以提高颈动脉斑块综合干预的临床认识。方法:应用高频超声对102例符合进展期脑卒中病人颈动脉斑块积分及易损性进行评估,分析颈动脉斑块积分、易损性与生化指标(包括空腹血浆葡萄糖、总胆固醇、三酰甘油、高密度脂蛋白、低密度脂蛋白、脂蛋白a、同型半胱氨酸、C反应蛋白、纤维蛋白原)的相关性。结果:102例进展期脑卒中病人共检出301个斑块,其中易损斑块257个(85.4%);颈动脉斑块平均积分为(11.24±4.56)mm;颈动脉斑块积分和空腹血浆葡萄糖、低密度脂蛋白、脂蛋白a、同型半胱氨酸、C反应蛋白、纤维蛋白原均呈正相关关系(P<0.01),和高密度脂蛋白呈负相关关系(P<0.05)。脂蛋白a、同型半胱氨酸及C反应蛋白是斑块易损性发生的独立危险因素(P<0.05)。结论:进展期脑卒中病人颈动脉斑块与生化指标密切相关,其中脂蛋白a、同型半胱氨酸及C反应蛋白是斑块易损性的危险因素。
Objective:To explore the carotid plaque integral,analyze the correlation between carotid plaque vulnerability and biochemical indicator in patients with progressive stroke for increasing the clinical knowledge of comprehensive intervention in carotid plaque.Methods:The integral and vulnerability of carotid plaques in 102 patients with progressive stroke were evaluated,and the correlations between carotid plaque vulnerability and biochemical indicators(fasting plasma glucose,total cholesterol,triglycerides,high-density lipoprotein cholesterol,low-density lipoprotein cholesterol,lipoprotein a,homocysteine,C reactive protein and fibrinogen)were analyzed.Results:Three hundred and one plaques in 102 patients with progressive stroke were detected,which included 257 vulnerable plaques(85.4%,257/301),and the mean integral of carotid plaques was(11.24±4.56)mm.There were positive correlations between the mean integral of carotid plaques,and fasting plasma glucose,low density lipoprotein,lipoprotein a,homocysteine,C reactive protein and fibrinogen(P<0.01),and there was negative relation between the mean integral of carotid plaques and high density lipoprotein(P<0.05).The lipoprotein a,homocysteine and C reactive protein were the independent risk factors of vulnerable plaques(P<0.05).Conclusions:The carotid plaques nature is closely related to biochemical indicator in patients with progressive stroke,and the lipoprotein a,homocysteine and C reactive protein are the independent risk factors of vulnerable plaques.
作者
何爽
江海强
HE Shuang;JIANG Hai-qiang;HE Shuang(Ultrasound Room,Jiangyin Traditional Chinese Medicine Hospital;Laboratory Medicine,Jiangyin Traditional Chinese Medicine Hospital,Jiangyin Jiangsu 214402,China)
出处
《蚌埠医学院学报》
CAS
2017年第12期1630-1633,共4页
Journal of Bengbu Medical College
