摘要
目的探究老年肺癌骨转移患者应用唑来膦酸与化疗配合治疗的临床疗效。方法选择2015年10月~2016年10月在杞县人民医院接受治疗的老年肺癌骨转移患者54例作为临床研究对象,根据随机数字表法分为对照组、观察组。对照组27例患者给予常规化疗治疗,观察组27例患者在对照组的基础上配合唑来膦酸进行治疗,比较所有患者经三个疗程治疗后的临床疗效、血清钙离子以及碱性磷酸酶值的变化情况。结果观察组患者的总有效率(96.30%)显著高于对照组患者的总有效率(62.96%);观察组患者的AKP值(119.01±31.13)U/L以及Ca^(2+)(1.59±0.17)mmol/L的值显著低于对照组患者的AKP值(195.99±34.78)U/L以及Ca^(2+)(2.54±032)mmol/L,差异具有统计学意义(P<0.05)。结论应用唑来膦酸与化疗配合治疗老年肺癌骨转移患者,效果理想,安全性高,提高患者的生活质量,值得在临床上广泛推广应用。
Objective To investigate the clinical efficacy of zoledronic acid combined with chemotherapy in the treatment of bone metastases in elderly patients with lung cancer.Methods A total of 54 cases of elderly patients with lung cancer were enrolled from October 2015 to October 2016.All subjects were randomized into the control group and observation group using random number table,27 cases in each group.The control group was treated with routine chemotherapy.The observation group received zoledronic acid on the basis of the control group.The clinical efficacy,serum calcium and alkaline phosphatase value were compared.Results The overall effective rate was significantly higher in the observation group than in the control group(96.30%vs 62.96%,P<0.05).The AKP and Ca2+level in the observation group were significantly lower than those in the control group((119.01±31.13)U/L vs(195.99±34.78)U/L,(1.59±0.17)mmol/L vs(2.54±032)mmol/L,and the difference was statistically significant(P<0.05).Conclusion Application of zoledronic acid and chemotherapy in the treatment of elderly patients with lung cancer bone metastases is effective and safe.The combined treatment can improve the quality of life,which is worthy of clinical application.
作者
赵建新
ZHAO Jian-xin(Department of Oncology,Qixian People’s Hospital,Kaifeng,Henan,475000,China)
出处
《临床研究》
2018年第2期41-43,共3页
Clinical Research
关键词
老年肺癌骨转移
化疗
唑来膦酸
临床疗效
elderly lung cancer bone metastasis
chemotherapy
zoledronic acid
clinical efficacy
