摘要
目的分析探讨Ⅲb期NSCLC同步放化疗前后血清肿瘤标志物的水平变化,并评估临床治疗效果。方法选取我院在2010年1月~2015年12月期间所收治的局部晚期非小细胞肺癌患者70例作为研究对象,对患者施以同步放化疗,然后检测患者血清肿瘤标志物的水平变化并结合疗效进行分析。结果同步放化疗后,有效患者血清肿瘤标志物除NSE外,其余各指标水平比治疗前均明显下降,对比差异明显(P<0.05);且经同步放化疗后,CR患者0例,PR患者有17例,患者血清肿瘤标志物除NSE外,CEA及CA125的水平均比治疗前明显下降;PD患者有28例,患者血清肿瘤标志物除NSE外,CEA及CA125的水平均比治疗前明显上升(P<0.05);SD患者25例,患者血清肿瘤标志物的水平与治疗前均无显著性差异(P>0.05)。结论Ⅲb期NSCLC患者施以同步放化疗后,有效患者血清肿瘤标志物得到明显改善,且CEA及CA125水平的动态变化可以作为临床疗效评价的参考指标,具有广泛的临床应用价值。
Objective To investigate the changes of serum tumor markers in patients with stage III and NSCLC B before and after radiotherapy and chemotherapy,and to evaluate the effect of clinical treatment.Methods Patients with locally advanced admitted to our hospital during January 2010-2015 year in December patients with non-small cell lung cancer in 70 cases as the research object,the patients with concurrent chemoradiotherapy,and detection of tumor markers in sera of patients with changes in the level of material and combined with the analysis of the effect.Results After concurrent chemoradiotherapy,effective in patients with serum tumor markers except NSE,the rest of the index level than before treatment were significantly decreased,the difference was significant(P<0.05);and after chemoradiotherapy,0 cases of CR patients,PR patients with 17 cases,serum tumor markers except NSE.CEA and CA125 levels were significantly decreased than those before treatment;28 cases of PD patients,serum tumor markers except NSE,CEA and CA125 levels were significantly increased than before treatment(P<0.05);25 cases of SD patients,and the level of tumor markers in sera of patients with the treatment before there was no significant difference(P>0.05).Conclusion NSCLC patients with stage B radiotherapy after chemotherapy,effective in patients with serum tumor markers were significantly improved,the reference index and dynamic changes of CEA and CA125 levels can be used as evaluation of clinical curative effect,which has broad clinical application value.
作者
范向辉
FAN Xiang-hui(radiotherapy department,the second people’s Hospital of Henan,Pingdingshan,Henan,467000,China)
出处
《临床研究》
2018年第2期43-45,共3页
Clinical Research
