摘要
目的观察沙丁胺醇与氨溴索联合雾化吸入治疗老老年慢性阻塞性肺疾病急性加重期的临床效果。方法选取86例老年慢性阻塞性肺疾病急性加重期患者,随机分为对照组和观察组,每组43例,在常规治疗基础上,对照组给予盐酸氨溴索雾化吸入治疗,观察组在对照组基础上给予硫酸沙丁胺醇雾化吸入治疗。连续治疗10 d后,比较2组患者治疗前后血气[动脉血酸碱度(PH值)、动脉血氧分压(Pa O2)、动脉血二氧化碳分压(Pa CO2)、血氧饱和度(Sa O2)]、肺功能[第1秒用力呼气量(FEV)、用力肺活量(FVC)、第1秒用力呼气量与用力肺活量比值(FEV1/FVC)]的变化,2组患者治疗后排痰量、喘息消失时间、咳嗽消失时间、肺部啰音消失时间的差异及不良反应发生率,评价治疗疗效。结果观察组血气及肺功能治疗改善明显,排痰量显著增多,喘息消失时间、咳嗽消失时间及肺部啰音消失时间均显著短于对照组(P<0.05),治愈率和总有效率显著高于对照组(P<0.05),不良反应差异无统计学意义(P>0.05)。结论沙丁胺醇联合氨溴索雾化吸入治疗老年慢性阻塞性肺疾病急性加重期能改善明显血气及肺功能,有症状体征改善快,治愈率高的优势,值得在老年COPD患者中推广使用。
Objective To observe the clinical effects of salbutamol combined with ambroxol aerosol inhalation on chronic obstructive pulmonary disease(COPD)at acute exacerbation period in the elderly.Methods Eighty-six elderly patients with COPD in acute exacerbation period were randomly divided into control group(n=43)and observation group(n=43).The patients in control group were treated by new atomization inhalation of ambroxol hydrochlorideon on the basis of routine treatment,however,the patients in observation group,on the basis of control group,were treated by salbutamol sulfate atomization inhalation.After 10-day treatment the changes of blood gas,arterial partial pressure of oxygen and carbon dioxide,oxygen saturation,pulmonary function and forced vital capacity were obseved and compared between the two groups.Moreover the difference of sputumn capacity,dispearing time of cough,wheezing and lung rales and incidence rate of adverse effect were also obseved and compared between two groups.Results The results showed that the blood gas and pulmonary function were significantly improved in oberservation group,the amount of sputum discharge was obviously increased,moreover,the disappearing time of cough and the disappearing time of wheezing and lung rales in oberservation group were significantly shorter than those in control group(P<0.05).In addition the cure rate and total effective rate in oberservation group were significantly higher than those in control group(P<0.05),however,there was no significant difference in incidence rate of adverse reactions between two groups(P>0.05).Conclusion The salbutamol combined with ambroxol aerosol inhalation in treatment of COPD at acute exacerbation period in the elderly can significantly improve blood gas and pulmonary function of patients,which has the advantages of fast improvement of symptoms and signs of patients as well as higher cure rate,therefor,which is worth using widely in clinical practice.
作者
马丽苹
李佳佳
赵清涛
MA Liping;LI Jiajia;ZHAO Qingtao(Cadre Ward,Bethune International Peace Hospital,Hebei,Shijiazhuang 050082,China)
出处
《河北医药》
CAS
2018年第6期845-848,共4页
Hebei Medical Journal
关键词
沙丁胺醇
氨溴索
雾化吸入
慢性阻塞性肺疾病
急性加重期
老年
salbutamol
ambroxol
aaerosol inhalation
chronic obstructive pulmonary disease
acute exacerbation stage
elderly patients
