摘要
目的:探讨血清类风湿因子(RF)、抗环瓜氨酸肽(抗CCP)抗体在类风湿性关节炎(RA)患者的表达与预后的相关性。方法:选取2015年1月-2016年6月本院收治的120例RA患者作为RA组,60例非RA患者作为非RA组,并以同期于本院体检部接受体检的60例健康体检者作为健康对照组。采用免疫透射比浊法检测观察对象的血清RF水平,采用酶联免疫吸附法(ELISA)检测观察对象的血清抗CCP抗体水平。分析RA患者血清RF、抗CCP抗体与肿胀关节计数(SJC)、压痛关节计数(TJC)和28个关节的疾病活动度(DAS28)评分的相关性。结果:RA组血清RF水平明显高于非RA组和健康对照组,差异均有统计学意义(P<0.05);RA组的血清抗CCP抗体水平明显高于非RA组和健康对照组,差异均有统计学意义(P<0.05)。RA活动组血清RF和抗CCP抗体水平均明显高于RA缓解组,差异均有统计学意义(P<0.05)。RA骨侵蚀组的血清抗CCP抗体水平均明显高于RA非骨侵蚀组,差异均有统计学意义(P<0.05)。Pearson分析结果显示,血清RF水平与DAS28呈显著正相关(P<0.05),血清抗CCP抗体水平与SJC、TJC和DAS28均呈显著正相关(P<0.05)。结论:血清RF和抗CCP抗体水平与RA疾病活动性相关,且血清抗CCP抗体水平与骨侵蚀相关。RF和抗CCP抗体在RA患者的早期诊断和预后评估中均具有较高的临床价值。
Objective:To discuss the expression level of rheumatoid factors(RF)and anti-cyclic citrullinated peptide antibody(anti-CCP)in patients with rheumatoid arthritis(RA)and its correlation to prognosis.Method:120 patients with RA from January 2015 to June 2016 were selected and taken as RA group,60 patients of non-RA were selected and taken as non-RA group,at the same time,60 healthy people who received physical examination in our hospital were taken as the healthy control group.The serum RF level was detected by immunoturbidimetric method,and the serum anti-CCP antibody level was detected by enzyme linked immunosorbent assay(Elisa).The correlation between serum RF,anti-CCP antibody and the scores of swelling joint count(SJC),tenderness joint count(TJC)and disease activity of 28 joints(DAS28)were analyzed.Result:The serum RF level in RA group was significantly higher than those in non-RA group and healthy control group,the differences were statistically significance(P<0.05);the level of anti-CCP antibody in RA group was significantly higher than those in non RA group and healthy control group,the differences were statistically significance(P<0.05).The levels of RF and anti-CCP in RA activity group were higher than those in RA remission group,the differences were statistically significance(P<0.05).The level of anti-CCP in bone erosion group was higher than that in non-bone erosion group,the difference was statistically significance(P<0.05).The results of Pearson analysis showed that there was a significant positive correlation between serum RF level and DAS28(P<0.05),there were significant positive correlations between serum anti-CCP antibody level and SJC,TJC and DAS28(P<0.05).Conclusion:RF and serum anti-CCP antibody levels associated with RA disease activity,and serum anti-CCP antibody levels associated with strands of erosion.RF and anti-CCP antibody in the early diagnosis and prognosis evaluation of patients with RA has high clinical value.
作者
张雪珍
ZHANG Xuezhen(The Central People’s Hospital of Huizhou City,Huizhou 516001,China)
出处
《中国医学创新》
CAS
2018年第9期27-30,共4页
Medical Innovation of China
基金
惠州市科技计划项目(20160801)
关键词
类风湿因子
抗环瓜氨酸肽抗体
类风湿性关节炎
预后
Rheumatoid factors
Anti-cyclic citrullinated peptide antibody
Rheumatoid arthritis
Prognosis
