PI3K/Akt信号通路在肝脏缺血再灌注损伤中的研究进展被引量：7

Research progresses of PI3K/Akt signaling pathway in hepatic ischemia-reperfusion injury

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摘要肝脏缺血再灌注损伤是导致术后肝脏功能延迟恢复和功能障碍的重要原因。有研究表明,PI3K/Akt信号通路在缺血和再灌注的过程中被激活,通过抑制或增强下游相关靶蛋白的表达发挥对肝脏的保护作用。因此,PI3K/Akt信号成为预防和改善肝脏缺血再灌注损伤的重要靶向通路。本文就PI3K/Akt信号通路在肝脏缺血再灌注损伤中作用的研究进展进行综述。 Liver ischemia-reperfusion injury is the leading cause of delayed recovery of liver function and dysfunction after operation.Some studies have shown that PI3K/Akt signaling pathway is activated during ischemia and reperfusion,which plays a protective role on the liver by inhibiting or enhancing the expressions of downstream target proteins.Therefore,PI3K/Akt signaling has become an important target pathway for preventing and improving hepatic ischemia-reperfusion injury.This review summarized the research progresses of PI3K/Akt signaling pathway in hepatic ischemia-reperfusion injury.

作者陈勇付贞范林熊艳叶啟发秦伟 CHEN Yong;FU Zhen;FAN Lin;XIONG Yan;YE Qi-fa;QIN Wei

机构地区武汉大学中南医院青海大学附属医院腹部腔镜外科中南大学湘雅三医院

出处《中国临床医学》 2018年第1期103-107,共5页 Chinese Journal of Clinical Medicine

基金国家自然科学基金新疆联合项目(U1403222)~~

关键词 PI3K/AKT 缺血再灌注损伤炎症反应氧化应激细胞凋亡自噬 PI3K/Akt ischemia-reperfusion injury inflammatory response oxidative stress apoptosis autophagy

分类号 R575 [医药卫生—消化系统]

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1王菲,贾莉莉,翁亦齐,杜洪印,喻文立.线粒体自噬在缺血再灌注损伤中作用的研究进展[J].中华器官移植杂志,2015,36(8):503-505. 被引量：3
2徐玉彬,张培建,毛旭南,张淼,胥广才,陶立德,张杰.凋亡和自噬在肝脏缺血再灌注损伤中的作用[J].中华医学杂志,2016,96(28):2274-2276. 被引量：6
3索立达,佟立权.PI3K-Akt信号传导通路在缺血再灌注损伤中的研究进展[J].河北医科大学学报,2014,35(2):237-240. 被引量：3
4Ning He,Jun-Jun Jia,Jian-Hui Li,Yan-Fei Zhou,Bing-Yi Lin,Yi-Fan Peng,Jun-Jie Chen,Tian-Chi Chen,Rong-Liang Tong,Li Jiang,Hai-Yang Xie,Lin Zhou,Shu-Sen Zheng.Remote ischemic perconditioning prevents liver transplantation-induced ischemia/reperfusion injury in rats: Role of ROS/RNS and e NOS[J].World Journal of Gastroenterology,2017,23(5):830-841. 被引量：19
5王超臣,张培建.线粒体自噬在肝相关疾病中的作用[J].中华普通外科学文献（电子版）,2013,7(5):55-57. 被引量：6
6毛长坤,刘付宝,耿小平.P38MAPK信号转导通路及其与缺血再灌注损伤的关系[J].肝胆外科杂志,2013,21(6):477-478. 被引量：2
7Chen Zhong,Li-Yong Pu,Ming-Ming Fang,Zhen Gu,Jian-Hua Rao,Xue-Hao Wang.Retinoic acid receptor α promotes autophagy to alleviate liver ischemia and reperfusion injury[J].World Journal of Gastroenterology,2015,21(43):12381-12391. 被引量：6
8吴鹏俐,钟坪杉,阳德飞,肖莉.肝缺血再灌注损伤分子机制的研究进展[J].局解手术学杂志,2017,26(6):461-464. 被引量：3

二级参考文献149

1李荣山,丁涛,刘晓城.SB203580对肾缺血/再灌注损伤时细胞凋亡及p38MAPK影响的实验研究[J].山西医科大学学报,2004,35(4):317-321. 被引量：16
2Wen-Xing Ding, Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, MS 1018, 3901 Rainbow Blvd, Kansas City, Kansas, KS 66160, United States.Role of autophagy in liver physiology and pathophysiology[J].World Journal of Biological Chemistry,2010,1(1):3-12. 被引量：10
3MIURA T, MIKI T. GSK-3beta, a therapeutic target for cardiomyocyte protection [ J J. Cire J,2009,73 (7) :1184 - 1192.
4MULLONKAL CJ,TOLEDO-PEREYRA LH. Akt in ischemia and reperfusion[ J ]. J Invest Surg,2007,20 (3) : 195 - 203.
5WANG B,SHRAVAH J, LUO H, et al. Propofol protects against hydrogen peroxide-induced injury in cardiac H9c2 ceils via Akt activation and Bcl-2 up-regulation [ J 1. Bioehem Biophys Res Commun,2009,389 ( 1 ) : 105 - 111.
6SONG JQ, TENG X, CAI Y, et al. Activation of Akt/GSK-313 signaling pathway is involved in intermedin1-53 protection against myocardial apoptosis induced by ischemia/reperfusion [ J ]. Apoptosis ,2009,14 ( 11 ) : 1299 - 1306.
7PARK SE, PARK C, KIM SH, et al. Korean red ginseng extract induces apoptnsis and decreases telomerase activity in human leukemia cells [ ]. ] Ethnopharmacol,2009,121 ( 2 ) : 304 - 312.
8SERVIDDIO G, DI VENOSA N, FEDERICI A, et al. Brief hypoxia before normoxic reperfnsion (postconditioning) protects the heart against ischemia-reperfusion injury by preventing mitochondria peroxyde production and glutathione depletion [ J ]. FASEB J,2005,19(3) :354 -361.
9SHIRASUGI N, WAKABAYASHI G, SHIMAZU M, et al. Up- regulation of oxygen derived free radicals by interleukin-1 in hepatic isehemia/reperfusion injury [ J ]. Transplantation, 1997, 64(6) :1398 - 1403.
10DONG C, GRANVILLE DJ, TUFFNEI CE, et al. Bax and apoptosis in acute and chronic rejection of root cardiac allografts [ J ]. Lab Invest, 1999,79 (12) : 1643 - 1653.