摘要
目的研究毛壳属真菌所致疾病及其菌种类型,了解其药敏状况。方法通过检索pubmed、万方数据库及中国期刊全文数据库中毛壳属真菌(Chaetomiumspp.)病例报告建立数据库进行描述性分析,时间限定为1983~2013年。结果共获得29篇文献,涉及35例患者。世界各地均有分布,以青中年为主,男性多于女性。侵袭性感染100%有基础疾病或存在诱发因素。感染涉及甲、皮肤、皮下组织、阴道、淋巴结、眼、鼻窦、耳部、肺、脑等组织和器官。浅部感染病程多呈慢性,治疗有效率66.67%。系统性感染预后较差,多数病例对两性霉素B不敏感,死亡率为85.71%。所有病例通过真菌培养确诊,多数病例组织病理中检测到真菌。侵袭性感染主要致病菌种分别为球毛壳(28.57%)、瘤突毛壳(21.43%)、暗褐毛壳(14.29%)及透亮毛壳(14.29%),浅表感染主要菌种为球毛壳(66.67%)。结论毛壳菌引起的感染类型广泛,不同部位毛壳菌感染临床表现不同,组织病理及反复真菌检查对确诊有重要帮助,特殊真菌感染需要引起临床工作者重视。
Objective Perform systamic review on Chaetomium infection case reports in literature.Methods Descriptive analysis was done with Chaetomium infection case reports over the world during recent thirty years.Results 35 patients in 29 literatures were analyzed.Every age group was involved world-widely,with young-and-middle age dominated and more males than females.100%patients of invasive infections had a primary disease or inducement,responsed poorly to amphotericin B.The mortality rate was 85.71%.The course of most superficial infections was chronic,with a total effective rate of 66.67%.All cases were confirmed by fungal culture.Most invasive infections were coursed by C.globosum(28.57%),C.strumarium(21.43%),C.atrobrunneum(14.29%)and C.perlucidum(14.29%),while C.globosum(66.67%)was the main pathogen of superficial infections.Conclusion Chaetomium can cause various infections,which clinical features are different among different rejoins involved.Histopathology and mycological examination is beneficial for diagnosis.Physicians should pay more attention to specific fungal infection.
作者
黄芩
孙可欣
李东明
HUANG Qin;SUN Ke-xin;LI Dong-ming(Department of Dermatology,Peking University Third Unversity,Beijing 100191,China;School of Public Health,Peking University,Beijing 100191,China)
出处
《中国真菌学杂志》
CSCD
2018年第1期34-39,共6页
Chinese Journal of Mycology
基金
国家自然科学基金(81571967
31770013)
关键词
毛壳菌
真菌感染
系统性回顾
Chaetomium
fungal infection
systematic review
