摘要
目的探讨雷公藤多苷片对慢性特发性荨麻疹患者血清内皮抑素及凝血酶敏感蛋白-1(TSP-1)的影响。方法将118例慢性特发性荨麻疹患者分为观察组和对照组,每组各59例。对照组采用地氯雷他定片治疗。观察组在对照组治疗的基础上,采用雷公藤多苷片治疗。评估患者的风团大小、风团数目、发作次数、瘙痒程度、持续时间等临床症状改善情况。检测两组患者治疗前后血清内皮抑素、TSP-1水平。结果观察组患者总有效率明显高于对照组,差异有统计学意义(P<0.05);治疗后,两组患者的风团大小、风团数目、发作次数、瘙痒程度、持续时间、症状总评分(TSS)较治疗前均明显降低;观察组的风团大小、风团数目、发作次数、瘙痒程度、持续时间、TSS明显低于对照组,差异均有统计学意义(P<0.05);治疗后,两组患者的内皮抑素、TSP-1较治疗前均明显升高;观察组的内皮抑素、TSP-1明显高于对照组,差异均有统计学意义(P<0.05)。结论雷公藤多苷片能明显降低慢性特发性荨麻疹患者血清内皮抑素、TSP-1水平,值得临床推广。
Objective To investigate the effect of tripterygium wilfordii tablet on serum endostatin and thrombin sensitive protein-1(TSP-1)in patients with chronic idiopathic urticaria.Methods A total of 118 patients with chronic idiopathic urticaria were divided into observation group and control group,59 cases in each group.The control group was treated with desloratadine tablets only,the observation group was treated with tripterygium wilfordii tablet combined with desloratadine tablets.Wheal size,wheal number,attack frequency,degree of itching and duration of clinical symptoms between two groups were evaluated.The levels of serum endostatin and TSP-1 in the two groups were measured before and after treatment.Results The total effective rate of the observation group was significantly higher than that of the control group,difference was statistically significant(P<0.05).After treatment,both groups′wheal size,wheal number,attack frequency,duration,degree of itching and TSS scores were significantly lower than before;and all the indexes of the observation group were significantly lower than the control group(P<0.05).The levels of endostatin and TSP-1 in the two groups were significantly higher than those before treatment.The levels of endostatin and TSP-1 in the observation group were significantly higher than those in the control group,the differences were statistically significant(P<0.05).Conclusion Tripterygium wilfordii tablet can significantly decrease the levels of serum endostatin and TSP-1 in patients with chronic idiopathic urticaria,it is worthy of popularization in clinic.
作者
周美联
卢明辉
刘纪朋
刘丽丽
尹保会
高顺强
ZHOU Meilian;LU Minghui;LIU Jipeng;LIU Lili;YIN Baohui;GAO Shunqiang(Department of Dermatology,People′s Hospital of Dingzhou,Dingzhou,Hebei 073000 China;Department of Dermatology,The Fourth Affiliated Hospital of Hebei Medical University,Shijiazhuang,Hebei 050000,China)
出处
《检验医学与临床》
CAS
2018年第7期973-975,共3页
Laboratory Medicine and Clinic
