摘要
目的观察三七皂苷(SAT)对豚鼠肺损伤的治疗作用并研究其作用机制。方法 120只豚鼠随机分为T0组、TS组、SAT组、FS组。采用硫化氢制备豚鼠肺损伤模型,构模8 h后停止给药,乙醚麻醉动物,分别于7h、14h、21h及24h时间点观测其肺损伤程度及病理变化。结果在各时间点观察:SAT能有效降低SWW浓度及肺静脉高压,与T0组、TS组比较差异具有统计学意义(P<0.05);但SAT与激素联合治疗效果差异并不明显,与FS组比较差异无统计学意义(P>0.05)。结论 SAT能有效抑制硫化氢引起的肺损伤进程。
Objective To investigate the effective and mechanism of panax notoginseng saponins(SAT)on acute lung injury(ALI)caused by hydrogen sulfide in guinea pigs.Methods 120 guinea pigs were randomized into group T0,group TS,group SAT and group FS.The ALI model of guinea pigs was established by hydrogen sulfide.The drug was removed 8 hours after the model was established.The animals were anaesthetized by aether.The degree of lung injury and pathological changes were observed at 7th,14th,21st and 24th hour.Results Compared with group T0 and TS,SAT could decrease the level of SWW and high pulmonary venous pressure significantly at every time point(P<0.05).However,compared with group FS,the effectiveness of SAT was not significantly different from that of combined treatment of hormone(P>0.05).Conclusion SAT could inhibit the process of lung injury caused by hydrogen sulfide effectively.
作者
陶政华
刘洪铨
TAO Zhenghua;LIU Hongquan(Hun'nan District Central Hospital of Shenyang City,Shenyang 110000,China)
出处
《中国现代医生》
2018年第8期32-34,共3页
China Modern Doctor
关键词
三七总皂苷
硫化氢
急性肺损伤
肺静脉压
Total saponins of panax notoginseng
Hydrogen sulfide
Acute lung injury
Pulmonary venous pressure
