摘要
目的 探讨玻璃体腔雷珠单抗注射联合激光治疗对糖尿病视网膜病变（DR）患者术后视网膜厚度及并发症发生率的影响。方法 选取本院2015年8月至2017年4月DR患者82例，随机数字表法分为对照组与研究组，各41例。对照组采取激光治疗（间隔1～2周进行1次治疗，共治疗3次），研究组于对照组基础上采取玻璃体腔雷珠单抗注射。统计两组临床疗效、治疗前及治疗后3个月视网膜厚度及视力水平、并发症（色觉异常、瞳孔损伤、角膜水肿、眼压增高）发生率。结果 两组治疗总有效率比较，研究组[90.24%（37/41）]高于对照组[73.17%（30/41）]，P＜0.05；治疗前两组视网膜厚度及视力水平比较差异无统计学意义（P＞0.05），治疗后3个月两组视网膜厚度较治疗前减小，视力水平较治疗前提高，且研究组视网膜厚度[（304.15±34.28）μm]小于对照组[（367.24±31.15）μm]，视力水平[（0.56±0.18）]高于对照组[（0.39±0.16）]，均P＜0.05；研究组并发症发生率为9.76%（4/41），对照组为29.27%（12/41），两组并发症发生率比较，P＜0.05。结论 联合采取激光及玻璃体腔雷珠单抗注射治疗糖尿病视网膜病变患者，可有效降低其视网膜厚度，改善视力水平，提高治疗效果，且可降低并发症发生风险，具有安全性。
Objective To investigate the effects of the intravitreal ranibizumab injection combined with laser therapy on the retinal thickness and the incidence of complications in patients with diabetic retinopathy(DR).Methods A total of 82 cases of DR treated at our hospital from August,2015 to April,2017 were selected and were randomly divided into a control group and a study group,41 cases for each group.The control group were treated with laser once every of 1-2 weeks for 3 times;in addition,the study group were treated with intravitreal ranibizumab injection.The clinical efficacy,retinal thickness,and visual acuity before and 3 months after the treatment and the incidence of complications(color vision,pupil damage,corneal edema,and ocular hypertension)in the two groups were statistically analyzed.Results The total effective rate was 90.24%(37/41)in the study group and was 73.17%(30/41)in the control group(P<0.05).There were no statistical differences in the retinal thickness and the visual acuity between the two groups before the treatment(P>0.05).The retinal thickness of the two groups decreased in 3 months after treatment and the visual acuity was higher than those before the treatment.The retinal thickness was thinner and the visual acuity was higher in the study group than in the control group[(304.15±34.28)μm vs.(367.24±31.15)μm and(0.56±0.18)vs.(0.39±0.16),P<0.05].The incidence of complications was 9.76%(4/41)in the study group and was 29.27%(12/41)in the control group(P<0.05).Conclusion Intravitreal ranibizumab injection combined with laser therapy for patients with diabetic retinopathy can effectively reduce the retinal thickness and the risk of complications and improve the vision level and the treatment effect of,and reduce and is safe.
作者
齐瑞荣
Qi Ruirong(Department of Ophthalmology,Huaxian People's Hospital,Anyang 456400,China)
出处
《国际医药卫生导报》
2018年第8期1189-1192,共4页
International Medicine and Health Guidance News
