摘要
目的明确草酸艾司西酞普兰联合重复经颅磁刺激治疗惊恐障碍患者的临床有效及安全性。方法惊恐障碍患者使用随机数表法等量分为联合治疗组38例(r TMS联合草酸艾司西酞普兰)和对照组(单一用药)38例,疗程8周。使用汉密尔顿焦虑量表(HAMA)以及治疗中出现的症状量表(TESS)在治疗前、治疗后2、4、8周评估疗效、不良反应。结果联合治疗组显效率89.2%,对照组为86.1%,无统计学差异(P=0.134)。两组HAMA评分在治疗后2、4周有统计学意义(P=0.023;P<0.013),惊恐障碍发作次数在治疗后2周有统计学意义(P=0.031)。治疗8周HAMA评分及惊恐障碍发作次数无统计学意义。两组药物用量、TESS评分具有统计学意义。结论 rTMS联合草酸艾斯西酞普兰治疗惊恐障碍起效迅速,疗效及安全性优于单纯药物治疗。
Objective To measure the clinical efficiency and safety of repetitive tanscranial magnetic stimulation(rMTS)combined with escitalopramon in the treatment of panic disorder.Method Seventy-six patients with panic disorder diagnosis who agreed to join this trial were randomly divided into combination group(rTMS plus escitalopram,38 patients)and control group(escitalopram only,38 patients).At the beginning of the trial and the end of two,four and six weeks after the treatment,the Hamilton anxiety scale(HAMA)and the treatment emergent symptoms scale(TESS)were examined to analyze the outcome and side effects.Results At the end of treatment,the marked response rate of combination group was not significantly higher than that in control group(P=0.134).The difference of HAMA score was detected at 2 and 4 but not 8 weeks after treatment(P=0.023;P<0.013).The significance of the dose of escitalopramand the TESS score was also detected between two groups.Conclusion The patients treated with rTMS plus escitalopram show more quickly clinical remission,better clinical outcome,rare adverse reaction.
作者
黄璐
涂卫丰
HUANG Lu;TU Wei-feng(Baoan District Chronic Disease Prevention and Cure Hospital,Shenzhen,Guangdong 518000,China)
出处
《实用医药杂志》
2018年第2期158-160,共3页
Practical Journal of Medicine & Pharmacy
基金
深圳市科技创新委员会资助项目(JCYJ20160429185854999)
关键词
惊恐障碍
草酸艾司西酞普兰
重复经颅磁刺激
疗效
Panic disorder
Escitalopram
Repetitive tanscranial magnetic stimulation
Efficacy
