摘要
目的探讨尼莫地平联合阿托伐他汀治疗重型颅脑损伤术后继发脑梗死患者临床治疗效果。方法选择解放军第一医院2014年5月—2016年10月期间创伤性重型颅脑损伤术后脑梗死患者共45例,随机分为观察组(n=23)和对照组(n=22)。对照组在术后脑梗死出现后常规维持血容量基础上脱水降颅压,尼莫地平、糖皮质激素、低分子右旋糖酐及神经营养、能量支持对症处理等治疗;观察组则是在对照组治疗基础上采用尼莫地平联用阿托伐他汀治疗。评定两组治疗效果。结果观察组患者中23例患者经治疗后19例存活(术后访3~6个月,按格拉斯哥结局量表(GOS)评分重度残疾5例,中残8例,恢复良好7例),死亡3例,死亡率占13.0%;对照组患者中22例患者经治疗后13例存活(术后访3~6个月,按GOS评分重度残疾6例,中残4例,恢复良好3例),死亡9例,死亡率占40.9%,两组死亡率比较差异有统计学意义(χ~2=4.465,P<0.05)。结论尼莫地平联合阿托伐他汀治疗重型颅脑损伤术后继发脑梗死患者更有效,更有利于脑组织创伤恢复。
Objective To study the postoperative clinical therapeutic effect of nimodipine plus atorvastatin on severe head injury secondary to cerebral infarction.Methods 45 cases of severe craniocerebral injury after cerebral infarction selected from May 2014 to October 2016 were randomly divided into the observation group(23 cases)and the control group(22 cases).The control group was treated normally to maintain blood volume after the onset of dehydration of intracraninal pressure.It was given nimodipine,glucocorticoid,low molecular dextran,nerve nutrition and energy support.The observation group received nimodipine plus atorvastatin more.Therapeutic effects of two groups were evaluated.Results 19 cases survived in the observation group.Postoperative visit for 3～6 months was carried.According to GOS scores,there was severe disability in 5 cases,residual in 8 cases and good recovery in 6 cases.4 cases died,the mortality rate was 17.39%.13 cases survived in the control group.There was severe disability in 6 cases,residual in 4 cases and good recovery in 3 cases.9 cases died,the mortality rate was 40.90%.Conclusion Treating severe head injury secondary to cerebral infarction by nimodipine plus atorvastatin is more effective,more conducive to brain tissue wound healing.
作者
樊新建
骆淑娥
栗宝鹏
潘奇
邢娟
杜东鹏
FAN Xin-jian;LUO Shu-e;LI Bao-peng;PAN Qi;XING Juan;DU Dong-peng(Department of neurosurgery,First Hospital of People's Liberation Army,Lanzhou 730030,China)
出处
《中国全科医学》
CAS
北大核心
2017年第B12期73-74,共2页
Chinese General Practice
关键词
重型颅脑损伤
脑梗死
尼莫地平
阿托伐他汀
Severe craniocerebral injury
Cerebral infarction
Nimodipine
Atorvastatin.
