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慢性心力衰竭与维生素D缺乏、甲状旁腺激素水平的相关性 被引量:4

Correlation between chronic heart failure and vitamin D deficiency,parathyroid hormone level
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摘要 目的探讨维生素D(VD)、血清甲状旁腺激素水平与慢性心力衰竭严重程度的相关性。方法选择射血分数减低的心衰患者97例,电化学发光法检验1,25羟维生素D3水平,化学发光法测甲状旁腺激素(PTH)水平,分析慢性心力衰竭与维生素D缺乏、甲状旁腺激素水平相关性。结果不同维生素D水平患者的心功能无显著差异。相关性分析发现,NYHA分级与维生素D存在负相关(r=-0.210,P=0.039),与PTH存在正相关(r=0.356,P=0.000),与VD/PTH存在负相关(r=-0.388,P=0.000);心功能越差,PTH水平越高,VD/PTH比值越低,差异有统计学意义(P<0.05)。维生素D水平也随着心功能减低而下降。结论在射血分数下降的心衰(HFr EF)患者中,心功能越差,维生素D水平越低,VD/PTH水平越低,PTH水平越高。 Objective To explore the correlation between vitamin D,serum parathyroid hormone level and the severity of chronic heart failure.Methods Totally 97 heart failure patients with reduced left entricular ejection fraction were selected.The electrochemical luminescence test was used to detect level of 1,25 hydroxyvitamin D 3,and chemiluminescence method was used to detect PTH level.Correlation between chronic heart failure and vitamin D deficiency,parathyroid hormone level.Results There were no significant differences in cardiac function between patients with different vitamin D levels.The correlation analysis showed that NYHA classification was negatively correlated with vitamin D(r=-0.210,P=0.039),positively correlated with PTH(r=0.356,P=0.000),and negatively correlated with VD/PTH(r=-0.388,P=0.000).The worse cardiac function indicated the higher PTH level and lower VD/PTH ratio,and there were significant differences(P<0.05).Vitamin D level decreased with the decrease of heart function.Conclusion In patients with HFrEF,the worse cardiac function may indicate the lower levels of vitamin D and VD/PTH as well as the higher PTH level.
作者 郁娃林 白剑 王彦涵 徐南娇 王涟 YU Walin;BAI Jian;WANG Yanhan;XU Nanjiao;WANG Lian(Department of Cardiovascular Medicine,Drum Tower Clinical Medical College of Nanjing Medical University,Nanjing,Jiangsu,210029)
出处 《实用临床医药杂志》 CAS 2018年第7期23-26,共4页 Journal of Clinical Medicine in Practice
关键词 心力衰竭 维生素D 甲状旁腺激素 心功能 射血分数 heart failure vitamin D parathyroid hormone cardiac function ejection fraction
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