摘要
目的探讨布地奈德联合沙丁胺醇雾化吸入治疗慢性阻塞性肺疾病急性加重期(AECOPD)的临床效果。方法选取我院2016年1月~2017年3月收取的270例AECOPD患者,随机分为布地奈德单药组、沙丁胺醇单药组和联合组,分别称作A、B、C组。三组患者均给予基本治疗,在基本治疗的基础上,A组患者给予布地奈德混悬液,B组患者给予硫酸沙丁胺醇,C组患者给予布地奈德混悬液+硫酸沙丁胺醇。观察三组患者的临床疗效、6 min步行距离(6MWD)、呼吸困难评分及肺功能等指标变化以及不良反应发生情况。结果 C组的总有效率为96.67%,显著高于A、B组(P<0.01)。A、B组的总有效率比较,差异无统计学意义(P>0.05)。A、B、C三组治疗后的6 MWD评分、呼吸困难评分及肺功能指标均有显著改善(P<0.01),且C组的改善幅度显著高于A、B组(P<0.05),但A、B组治疗后的6 MWD评分、呼吸困难评分及肺功能指标比较,差异无统计学意义(P>0.05)。三组的不良反应发生率比较,差异无统计学意义(P>0.05)。结论在AECOPD治疗中,布地奈德联合沙丁胺醇雾化吸入与单药吸入相比,临床疗效更好,更能显著改善临床症状和肺功能,且不良反应发生率低,值得在临床上广泛推广。
Objective To investigate the clinical effect of Budesonide combined with Salbutamol Aerosol Inhalation in the treatment of acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods A total of 270 AECOPD patients collected in our hospital from January 2016 to March 2017 were selected and randomly divided into the Budesonide monotherapy group,the Salbutamol monotherapy group and the combination group,which were called group A,B and C.The three groups were all given basic treatment.On the basis of basic treatment,patients in group A were given Budesonide suspension,group B was given Salbutamol Sulfate,group C was given Budesonide suspension and Salbutamol Sulfate.The clinical efficacy,6 min walking distance(6 MWD),dyspnea score and lung function were observed in the three groups,as well as the occurrence of adverse reactions.Results The total effective rate of group C was 96.67%,which was significantly higher than that of group A and B(P<0.01).There was no significant difference in the total efficiency of group A and B(P>0.05).Meanwhile,after treatment,the 6MWD scores,dyspnea scores and pulmonary function indexes of the three groups of A,B and C improved significantly(P<0.01),and the improvement rate of group C was significantly higher than that of group A and B(P<0.05),but there was no significant difference between group A and B(P>0.05).There was no significant difference in the incidence of adverse reactions between the three groups(P>0.05).Conclusion In the treatment of AECOPD,Budesonide combined with Salbutamol Aerosol Inhalation is better than that single drug inhalation.It has better clinical effect,which can significantly improve the clinical symptoms and lung function,and the incidence of adverse reactions is low.It is worth promoting widely in clinic.
作者
黎燕
LI Yan(Department of Internal Medicine,Hospital of Traditional Chinese Medicine of Sihui City in Guangdong Province,Sihui 526200,China)
出处
《中国当代医药》
2018年第8期24-26,30,共4页
China Modern Medicine
关键词
布地奈德
沙丁胺醇
雾化吸入
慢性阻塞性肺疾病
临床疗效
Budesonide
Salbutamol
Aerosol inhalation
Chronic obstructive pulmonary disease
Clinical efficacy
