摘要
目的:探究米索前列醇联合缩宫素对宫缩乏力性产后出血患者产后出血量及生活质量的影响。方法:选取2014年5月~2017年4月期间滑县中心医院收治的宫缩乏力性产后出血患者82例,依据治疗方案不同分为研究组与对照组,各41例。对照组予以缩宫素治疗,研究组予以缩宫素+米索前列醇治疗。统计两组第三产程时间、产后2h内出血量、产后出血率及不良反应率,并对比两组治疗前后血压及生活质量变化情况。结果:研究组第三产程时间较对照组短,产后2h出血量较对照组少,产后出血率较对照组低,差异有统计学意义(P<0.05);两组舒张压、收缩压治疗前差异无统计学意义(P>0.05);治疗后,两组舒张压、收缩压均有所下降,但组间相比,差异无统计学意义(P>0.05);研究组不良反应率12.20%(5/41)与对照组7.32%(3/41)相比,差异无统计学意义(P>0.05);两组生活质量各维度评分治疗前差异均无统计学意义(P>0.05);相较于对照组,治疗后研究组物质生活状态、心理、躯体及社会功能评分均较高,差异有统计学意义(P<0.05)。结论:联合采用米索前列醇与缩宫素治疗宫缩乏力性产后出血,可显著缩短第三产程时间,减少产后2 h内出血量,降低产后出血率及血压水平,有效改善患者生活质量,且安全性较高,值得临床推广、应用。
Objective:To investigate the effect of misoprostol combined with oxytocin on postpartum hemorrhage and quality of life of patients with uterine atony postpartum hemorrhage.Methods:A total of 82 cases of uterine atony postpartum hemorrhage in our hospital from May 2014 to April 2017 were selected and divided into the study group and the control group according to the treatment plan,41 cases in each.The control group was treated with oxytocin,and the study group was treated with oxytocin+misoprostol.The time of the third course of labor,2-h postpartum hemorrhage,postpartum hemorrhage rate and adverse reaction rate of two groups were statistically recorded.The changes of blood pressure and quality of life before and after treatment were compared between the two groups.Results:The time of the third course of labor in the study group was shorter than that in the control group,the amount of 2-h postpartum hemorrhage was less than that of the control group,and the rate of postpartum hemorrhage was signifincatly lower than that of the control group(P<0.05).There were insignificant differences in diastolic pressure and systolic pressure between the two groups before treatment(P>0.05).After treatment,the diastolic pressure and systolic pressure decreased in the two groups,but with insignificant differences between the groups(P>0.05).There were insignificant differences in the adverse reaction rate between 12.20%(5/41)in the study group and 7.32%(3/41)in the control group(P>0.05).There were insignificant differences between the two groups in quality of life before treatment(P>0.05).Compared with the control group,the scores of physical life,mental,physical and social function of the study group were all significantly higher after treatment(P<0.05).Conclusion:Misoprostol combined with oxytocin in patients with uterine atony postpartum hemorrhage can significantly shorten the time of the time of the third stage of labor,reduce the amount of 2-h postpartum hemorrhage,reduce the rate of postpartum hemorrhage and blood pressure,and effectively improve the quality of life of patients,and with high safety.Therefore,it is worthy of clinical promotion and application.
作者
张会遵
刘红
ZHANG Hui-zun;LIU Hong(Department of Gynecology and Obstetrics,Huaxian Central Hospital,Huaxian Henan,456400,China;Department of Gynaecology and Obstetrics,Anyang Third People's Hospital,Anyang Henan 455000,China)
出处
《药品评价》
CAS
2018年第7期52-54,64,共4页
Drug Evaluation
