摘要
口腔颌面部疼痛是常见的病症之一,极大地影响了患者的生活质量。口腔颌面部的感染、神经损伤、肿瘤等都可引起口腔颌面部疼痛。在中枢神经系统和外周神经系统中有P2X受体的表达。P2X受体为胞外ATP激活的非选择性阳离子通道,对伤害性感受传递起着重要作用。近年来,研究P2X受体与疼痛发生的关系已成为热点。研究表明在头面部初级感觉传入神经节三叉神经节有P2X受体的表达,其在颌面部疼痛中的作用以及具体机制值得深入研究。本文对P2X受体在口腔颌面部的炎症性疼痛、神经病理疼痛和癌症疼痛等的作用研究进展做一综述,为口腔颌面部疼痛的预防和治疗提供新的思路。
Oral maxillofacial pain is one of the most common symptoms that greatly influences patients′quality of life.Infectious diseases,nerve injuries and tumors in the oromaxillofacial region can cause facial pain.P2X receptors are located in the central and peripheral nervous system.P2X receptors are non-selective cation channels that are activated by extracellular ATP and play an important role in nociceptive processing.In recent years,research into the rela-tionship between P2X receptors and pain has become popular.Research shows that P2X receptors are expressed in the trigeminal ganglia(TG)of the primary sensory ganglion,and the effects of P2X receptors on facial pain and their related conduction mechanisms are worthy of additional research.To provide new ideas for orofacial pain prevention and treatment,this article reviews the latest progress in research regarding the role of P2X receptors in inflammatory pain,neuropathic pain,and cancer pain,among others,of the oromaxillofacial region.
作者
何柃锟(综述)
熊伟(审校)
HE Lingkun;XIONG Wei(Medical College of Nanchang University,Nanchang 330006,China;Department of Preventive Dentistry,Affiliated Stomatology Hospital,Nanchang University,The Key Laboratory of Oral Biomedicine,Jiangxi Province,Nanchang 330019,China)
出处
《口腔疾病防治》
2018年第4期254-257,共4页
Journal of Prevention and Treatment for Stomatological Diseases
基金
国家自然科学基金项目(81460106)
江西省科技支撑计划项目(20142BBG70051)
