摘要
目的观察3%高渗盐水雾化吸入联合布地奈德、沙丁胺醇治疗小儿中重度毛细支气管炎的效果。方法选取2013年11月~2016年11月在廊坊市人民医院儿科就诊的451例1个月~2岁的毛细支气管炎患儿作为研究对象,采用随机数字表法将其分为对照组(n=227)和治疗组(n=224)。两组患者均采用常规治疗方法,对照组给予布地奈德+沙丁胺醇雾化吸入,治疗组在对照组的基础上加3%浓高渗盐水进行治疗。比较两组患者治疗后的临床效果、缺氧症状评分、各项症状持续时间、住院时间及不良反应发生情况。结果治疗后,治疗组患儿的治疗总有效率(86.2%)高于对照组(80.6%),差异有统计学意义(P<0.05)。治疗后第1、3、5天,治疗组患儿的缺氧症状评分均低于对照组,差异有统计学意义(P<0.05)。治疗组患儿的咳嗽持续、喘息持续、血气恢复及啰音消失时间均短于对照组,差异有统计学意义(P<0.05)。治疗组患儿的平均住院时间短于对照组,差异有统计学意义(P<0.05)。两组患儿的不良反应发生率比较,差异无统计学意义(P>0.05)。结论 3%高渗盐水雾化吸入联合布地奈德、沙丁胺醇治疗小儿中重度毛细支气管炎的效果显著,对毛细支气管炎患儿的治疗有一定的临床推广应用价值。
Objective To observe the therapeutic effect of 3%Hypertonic Saline atomization inhalation combined with Budesonide and Salbutamol in the treatment of moderate to severe bronchiolitis in children.Methods From November 2013 to November 2016,451 children with bronchiolitis,aged from 1 month to 2 years,who were admitted to the department of pediatrics in the People′s Hospital in Langfang City were selected as the study subjects.The subjects were randomly divided into the control group(n=227)and the treatment group(n=224)by random number table method.Two groups of patients were treated by conventional methods.In the control group,children were treated with Budesonide combined with Salbutamol inhalation,and the treatment group were treated on the basis of the control group plus 3%Hypertonic Saline.The clinical efficacy,hypoxia symptom score,duration of symptoms,hospital stay and adverse reactions were compared between the two groups.Results After treatment,the total effective rate in the treatment group(86.2%)was higher than that in the control group(80.6%),and the difference was statistically significant(P<0.05).After treatment 1,3,5 days,the scores of hypoxia symptom in the treatment group were lower than those in the control group,and the differences were statistically significant(P<0.05).The duration of coughing continued,the wheezing continued,the recovery time of blood gas and the time of sound disappeared in the treatment group shorter than those in the control group,and the differences were statistically significant(P<0.05).The average length of hospital stays in the treatment group was shorter than that in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The 3%Hypertonic Saline inhalation combined Budesonide and Salbutamol in the treatment of moderate to severe bronchiolitis in children is remarkable.This treatment method has certain clinical application value for the treatment of children with bronchiolitis.
作者
于冬辉
刘颖辉
李永红
于丽英
YU Dong-hui;LIU Ying-hui;LI Yong-hong;YU Li-ying(Second Department of Pediatrics,the People′s Hospital in Langfang City,Hebei Province,Langfang 065000,China;Department of Pediatrics,the Third People′s Hospital in Langfang City,Hebei Province,Langfang 065000,China)
出处
《中国当代医药》
2018年第9期80-82,86,共4页
China Modern Medicine
基金
河北省廊坊市科技计划项目(2016013177)
