摘要
目的:评价负压封闭引流(vacuum sealing drainage,VSD)对创伤伤口愈合情况的影响。方法:计算机检索Cochrane图书馆、Pubmed、爱思唯尔(Science Direct)、中国知网全文数据库(CNKI)、维普数据库(VIP)及万方数据库中关于负压封闭引流对创伤伤口愈合情况影响的随机对照试验。2名研究者独立检索文献、筛选文献、资料提取、评价纳入文献的方法学质量,双方核对讨论后,采用RevMan5.3软件进行Meta分析。结果:共纳入9篇文献,均为RCT。Meta分析结果显示:与传统敷料相比,负压封闭引流可以减少换药次数[MD=-7.46,95%CI(-9.13,-5.78),P<0.001],缩短创面愈合时间[MD=-7.48,95%CI(-11.84,-3.13),P<0.001]及住院天数[MD=-9.6,95%CI(-12.78,-6.42),P<0.001],差异有统计学意义,但在并发症发生率[Z=0.36,P=0.72>0.05]和伤口感染率[Z=0.69,P=0.49>0.05]方面,差异无统计学意义。结论:使用负压封闭引流处理创伤伤口对并发症发生率和伤口感染率无明显改善,但可以减少换药次数,缩短创面愈合时间和住院天数,值得临床推广。
Method:Literature about the effect of vacuum sealing drainage on woud healing was retrieved from digitallite-rature were all randomized controlled trials.Data were searched and extracted,c-aptured citations were screened,and methodlogical quality of all included studieswas assessed by 2 reviewers independently.RevMan 5.3 software was then usedto perform meta-analysis.Results:Nine published studies were included for s-ystematic review,and all were RCTs.The results of meta-analysis showed that,c-ompared with tradition dressing,vacuum sealing drainage had significantly decr-eased the dressing change times[MD=-7.46,95% CI(-9.13,-5.78),P<0.001],shortenwound healing days[MD=-7.48,95%CI(-11.84,-3.13),P<0.001]and length of stay[MD=-9.6,95%CI(-12.78,-6.42),P<0.001].But there was no statistically significa-nt difference between two groups in complication rate[Z=0.36,P>0.05]and infection rate[Z=0.69,P>0.05].Conclusion:The employ of vacuum sealingdrainage on therapy of wound healing has no significant improvememnt on co-mplication rate and infection rate compared with tradition dressing,but it can decrease dressing change times,shorten wound healing days and length of stay,so it deserve to be generaly used in clinic.
出处
《长江大学学报（自然科学版）》
CAS
2018年第8期62-68,共7页
Journal of Yangtze University(Natural Science Edition)
基金
2017年湖北省自然科学基金项目(2017CFB786)
