摘要
目的研究脂微球前列地尔对急性脑梗死(ACI)合并2型糖尿病(T2DM)患者的临床治疗价值。方法 112例ACI伴T2DM患者随机分为A组和B组,均行常规治疗,A组加用脂微球前列地尔10μg静脉滴注,1次/d,均治疗2 w,比较两组临床疗效和治疗前后神经功能缺损评分、Barthel指数、颈动脉斑块、血管内皮功能和炎症介质水平变化情况。结果 A组治疗总有效率显著高于B组(P<0.05);治疗后,两组神经功能缺损评分显著降低,Barthel指数显著上升,且A组变化幅度大于B组(P<0.05);两组颈动脉血流阻力指数、内-中膜厚度和斑块面积显著下降,斑块稳定性显著上升,血内皮素-1、血栓素B2显著降低,血管内皮细胞生长因子显著上升,可溶性细胞间黏附分子-1、核因子κB(NF-κB)显著下降,且A组变化幅度大于B组(P<0.05)。结论脂微球前列地尔治疗ACI合并T2DM的效果显著,主要与其减轻神经功能缺损,改善颈动脉斑块性质,保护血管内皮功能,减轻炎症反应有关。
Objective To study the clinical value of liposome prostaglandin in the treatment of ACI complicated by T2DM in patients.MeAods A total of 112 patients with ACI complicated by T2DM were randomly divided into tw-o groups,both receiving conventional treatment for two weeks,and on the basis of this,10μg intravenous injection of liposome prostaglandin was additionally performed on Group A once per day.The clinical effects,NIHSS scores before and after the treatment,Barthel indicators,carotid plaque,vascular endothelial function and change in inflammatory^mediator levels were compared between the two groups.Results The total effective rate of treatment of Group A was higher than that of Group<0.05);both groups showed significant decrease in NIHSS scores and great increase in Barthel indicators.In particular,Group A had a wider range than Group B<0.05).For both groups,the carotid artery RI,intima-media thickness and plaque area decreased significantly while the plaque stability improved greatly,plasm endothelin-1 and thromboiane B2 decreased greatly,vascular endothelial cell growth factor increased visibly and soluble intercellular adhesion molecule-1 and nuclear factor kB(NF-kB)decreased greatly.Group A had a wider range than Group B(P<0.05).Condusion Liposome prostaglandin is significantly effective in treating ACI complicated by T2DM,mainly contributing to reducing neurologic impairment,improving carotid plaque performance,protecting vascular endothelium and relieving inflammatory reaction.
作者
颜军梅
鲁锐
Yan Junmei;Lu Rui(Department of Neurology,Zigui County Traditional Chinese Medicine Hospital,Zigui,Hubei,443600,China;Department of Medicine,Zigui County Traditional Chinese Medicine Hospital,Zigui,Hubei,443600,China)
出处
《西南国防医药》
CAS
2018年第4期337-340,共4页
Medical Journal of National Defending Forces in Southwest China
