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乳腺癌干细胞标志物研究进展 被引量:5

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摘要 乳腺癌的复发和转移使其临床治疗难以取得令人满意的效果,肿瘤干细胞(CSCs)理论的提出为研究、治疗乳腺癌提供了新的思路。乳腺癌干细胞(BCSCs)具有多向分化、自我更新和耐药性等特征,在乳腺癌的发生、发展以及耐药、转移、复发等过程中起着重要的作用,是治疗乳腺癌的新靶点。寻找灵敏度高、特异度强的CSCs标志物对鉴别、分离乳腺癌干细胞有重要的意义。该文综述了乳腺癌中比较公认的CSCs标志物CD44/CD24、ALDH1及潜在的肿瘤干细胞标志物CD133、GD2、CD49f、ANTXR1的研究进展。
出处 《国际检验医学杂志》 CAS 2018年第8期970-974,共5页 International Journal of Laboratory Medicine
基金 国家自然科学基金资助项目(81641192)
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