摘要
随着年龄的增长,骨骼肌减少与动脉粥样硬化的发病率显著升高。近年来大量临床研究表明二者具有密切的相关性。然而骨骼肌减少导致动脉粥样硬化的机制并不确切。可能的机制包括:胰岛素抵抗、性激素水平下降、细胞因子炎症因子、自由基损伤、营养不良、低出生体重、细胞凋亡、线粒体损伤、卫星细胞作用。进行阻抗运动、增加蛋白质摄入、补充维生素D等措施对防治老年动脉粥样硬化有效。因此,有必要对二者相关的机制进行更深入、广泛的研究。
As the growth of the age,significantly increased the incidence of sarcopenia and atherosclerosis.In recent years a large number of clinical studies have shown that both have close correlation.However,the mechanism on how sarcopenia leads to atherosclerosis is not very clear yet.Including the possible mechanism:Insulin resistance,sex hormone levels drop,inflammatory cytokine factor,free radical damage,malnutrition,low birth weight,cell apoptosis,mitochondrial damage,satellite cells.Impedance movement,increase the protein intake,vitamin D supplement measures may be the possible prevention and treatment of senile atherosclerosis.Therefore,indepth and extensive reseaches are necessary in elucidating the underlying mechanisms.
作者
刘颖
高金娥
LIU Ying;GAO Jin-e(Baotou Medical College,Baotou 014000 China)
出处
《内蒙古医科大学学报》
2018年第1期89-93,共5页
Journal of Inner Mongolia Medical University
基金
国家自然科学基金(81460223)
内蒙古自治区自然科学基金(2016MS0869)
内蒙古自治区卫生和计划生育委员会医疗卫生科研计划项目(201301006)
内蒙古自治区科技计划项目基金(2017)
