摘要
镁合金作为一种新型的可降解生物医用金属材料,在力学性能、生物相容性和生物降解性能方面都具有优越性,目前在医用材料领域已成为研究热点。然而由于其存在腐蚀速率快和腐蚀不均等不足,这势必会阻碍它的应用及发展。因此对镁合金材料表面进行改性处理,增加耐腐蚀性,同时提高其生物相容性,已经成为可降解镁合金发展与应用中的重要组成部分。采用一种细胞内的天然高分子聚合物,即聚β-羟基丁酸酯(poly-beta hydroxy butyric acid ester,PHB)作为涂层材料,在WE43镁合金表面制备PHB涂层,考察改性后镁合金材料的表面形貌和生物相容性。实验结果表明,经聚合物PHB涂层后的WE43镁合金聚合物涂层分布较均匀,对镁合金有较好的保护作用。另外,PHB涂层明显提高了镁合金的血液相容性,对细胞的增殖起到了一定的促进作用,并有利于细胞迁移。该研究为可降解医用镁合金材料的研究提供一种新思路。
The magnesium alloys have been used as new types of degradable biomedical metal materials.Their mechanical properties,biocompatibility,biodegradation performance are excellent.In recent years,they have become the focus of research in the areas of medical materials.However,their corrosion rate is rapid and not uniform,which hinders their application and development.Therefore,surface modification,increasing the corrosion resistance and improving the biocompatibility have become important parts in development and application of degradable magnesium alloys.This paper used a kind of natural polymer in cells,namely poly-beta hydroxy butyric acid ester(PHB)as coating material.The surface morphology and biological compatibility of materials were investigated after preparing the PHB coating on WE43 magnesium alloy.The experimental results showed that the polymer coating was evenly distributed on the WE43 magnesium alloy surface and had a better protective effect on the materials.In addition,the PHB coating significantly improved the blood compatibility of magnesium alloy,promoted the proliferation and migration of cells.The research will provide a new way for the study of degradable magnesium alloy materials.
作者
葛淑萍
邹兴政
梁明月
葛爽
尹铁英
王贵学
许凯
GE Shuping;ZOU Xingzheng;LIANG Mingyue;GE Shuang;YIN Tieying;WANG Guixue;XU Kai(Chemical Engineering College of Chongqing University of Technology,Chongqing 400054,China;Biological Rheological Science and Technology,Key Laboratory of the Ministry of Education,Chongqing University,Chongqing 400044,China;Chongqing Materials Research Institute Co.,Ltd.,Chongqing 400707,China;China Coal Mining Group Chongqing Research Institute Co.,Ltd.,Chongqing 400039,China)
出处
《功能材料》
EI
CAS
CSCD
北大核心
2018年第4期4082-4088,4093,共8页
Journal of Functional Materials
基金
国家自然科学青年基金资助项目(31700826)
"生物流变科学与技术"教育部重点实验室资助项目(CQKLBST-2016-001)
重庆市基础与前沿研究计划资助项目(cstc2017jcyjA0948)
重庆理工大学星火计划资助项目(0115141304)
