摘要
肥胖相关性肾病(ORG)是一种与肥胖密切相关的疾病。肥胖是慢性肾脏病的独立危险因素,其通过影响肾脏血流动力学、血管紧张素-醛固酮系统、胰岛素抵抗等导致肾脏的结构和组织病理学发生改变,从而引起慢性肾病。ORG无特异性表现,大部分表现为缓慢进展的蛋白尿。减肥是治疗ORG最基本也是最简单、最有效的手段,此外适当运动、肾素-血管紧张素-醛固酮系统阻断剂、血管紧张素转换酶抑制剂以及血管紧张素受体拮抗剂也可用于ORG的治疗,减轻蛋白尿。
Obesity-related glomerulopathy(ORG)is a disease closely related to obesity.Obesity is an independent risk factor of chronic kidney disease,which can cause chronic kidney disease by affecting renal hemodynamics,angiotensin aldosterone system,insulin resistance leading to kidneys′structural and pathologic changes.ORG has no specific manifestation,most of which are slowly progressing albuminuria.Losing weight is the most basic and simple and effective way to treat ORG.Besides,proper exercise,renin-angiotensin-aldosterone system blockers,angiotensin-converting enzyme inhibitors and angiotensin receptor antagonists can also be used in treatment of ORG,which can reduce the proteinuria.
作者
许杨
焦军东
XU Yang;JIAO Jundong(Department of Nephrology,the Second Affiliated Hospital of Harbin Medical University,Harbin 150086,China)
出处
《医学综述》
2018年第5期936-940,共5页
Medical Recapitulate
关键词
肥胖相关性肾病
肾小球疾病
肥胖
高滤过
肾脏血流动力学
Obesity-related glomerulopathy
Glomerulopathy
Obesity
Hyperfiltration
Renal hemodynamics
