摘要
多模态融合的分子影像技术整合了多种分子影像技术的优势,已成为当前分子影像领域研究的热点和发展趋势。新近报道的七甲川菁(heptamethine cyanine)染料是一类具有肿瘤靶向性的近红外荧光(nearinfrared fluorescence,NIRF)制剂。该染料独特的光学特征使其在肿瘤分子影像、靶向治疗和药物传递系统方面具有广阔的应用前景。纳米材料包裹该类染料可用于NIRF/MRI双模成像,标记核素后可实现NIRF/PET双模成像,共轭结合化疗药物后,可实现抗肿瘤药物的靶向传递,多个七甲川菁染料的复合物已被用作多模态成像,成为光热、光动力学和组合治疗肿瘤的新策略。
Multi-modal fusion molecular imaging technology integrates the advantages of a variety of molecular imaging techniques,and has become a hotspot and trend in the field of molecular imaging.Heptamethine cyanine dye is a class of novel near-infrared fluorescence(NIRF)dye with tumor targeting properties.With its unique optical properties,the dye has broad application prospects in tumor molecular imaging,targeted therapy and drug delivery system.Nano-materials containing heptamethine cyanine dye can be used for NIRF/MRI dual-modal imaging.NIRF/PET dual-modal imaging can be achieved after labeling with nuclides.Conjugated with chemotherapy drugs,targeted delivery of anti-tumor drugs can also be achieved.Complexes of multiple heptamethine cyanine dyes have been used for multi-modal imaging as a new strategy for photothermal therapy,photodynamic therapy and combined treatment of tumors.
作者
师长宏
SHI Changhong(Laboratory Animal Center,the Fourth Military Medical University,Xi’an 710032,China)
出处
《中国实验动物学报》
CAS
CSCD
北大核心
2018年第2期234-238,共5页
Acta Laboratorium Animalis Scientia Sinica
基金
国家自然科学基金(No.31572340
No.31772546)
陕西省科技资源开放共享平台项目(No.2016FWPT-02)~~
关键词
近红外荧光
多模态成像
肿瘤模型
分子影像
near-infrared fluorescence dye
multi-modal imaging
tumor models
molecular imaging
