摘要
目的归纳肉桂成方制剂用药规律并分析相关不良反应文献,为诊疗合理用药提供借鉴。方法遴选《中华药典》(2015版)和《方剂学》("十二五"第2版)中含肉桂(油)成药制剂并检索1962—2017年中国期刊全文数据库(CNKI)收录相关药品不良反应/事件案例。结果收集含肉桂方剂50首、单方制剂1种、中成药285种、不良反应/事件30例。2000—2009年间分布较多(40.7%),其类型多为A型,提示有可预测性和剂量依赖性的特点。青、中年患者群中事件发生率较高(80%),主要影响皮肤及附件、感官系统;高频发生于用药60 min内、用药3~7 d、以及用药数月至半年内此3个服药周期中。结论不良反应发生原因主要与配伍、辨证、滥用误用及职业病因素有关。
objective To summarize the drug prescription of cinnamon and to analyze the related(Adverse drug reactions;ADR),and to provide reference for the rational use of drugs for diagnosis and treatment.Methods Cinnamon(oil)preparations were selected from the Chinese pharmacopoeia(2015 edition)and"Pharmacology of traditional Chinese medicine"("Twelfth Five-Year",second edition)and retrieved from the 1962-2017 China Journal Full-Text Database(CNKI)and statistically relevant adverse drug reactions was calculated.Results A total of 50 cinnamon prescriptions,1 single preparation,285 proprietary Chinese medicines,and 30 adverse reactions were collected.Between 2000 and 2009 there were more distributions(40.7%);Most of the adverse reactions were type A,suggesting a predictable and dose-dependent characteristic.The incidence of reaction in the young and middle-aged patients was high(80%),mainly affecting the skin and its accessories and sensory system.The high frequency occurred within 60 minutes of drug use,3~7 days of drug use,within 3 months of drug use and several months to six months of drug use.Conclusion The main causes of adverse reactions are related to compatibility,syndrome differentiation,abuse,misuse,and occupational diseases.Conclusion The reasons of ADR are mainly related to herb compatibility,wrong syndrome differentiation,misuse and occupational disease.
作者
纪越
王拓然
张可欣
周子钧
刘玉璇
JI Yue;WANG Tuo-ran;ZHANG Ke-xin;ZHOU Zi-jun;LIU Yu-xuan(School of Tianjin University of Chinese Medicine,Tianjin 300193,China)
出处
《中国药物警戒》
2018年第3期163-168,共6页
Chinese Journal of Pharmacovigilance
关键词
肉桂
成药
用药规律
不良反应
Cinnamon
Chinese patent medicine preparation
regularity
adverse drug reaction
