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孕激素受体调控排卵过程中卵泡破裂的机制 被引量：2

Progesterone receptor regulates the mechanism of follicular rupture during ovulation
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摘要 孕激素在雌性生殖活动尤其是排卵过程中是必不可缺少的。孕激素通过孕激素受体(progesterone receptor,PR)调节卵泡破裂进而诱发排卵。PR调节卵泡破裂要依赖其相关因子才能发挥作用,主要包括血小板反应蛋白解整合素金属肽酶-1(a disintegrin and metalloproteinase domain with thrombospondin motif-1,ADAMTS-1)、解整合素样金属蛋白酶8(a disintegrin and metalloprotease 8,ADAM8)、内皮素-2(endothelin-2,ET-2)、乏氧诱导因子-1α(hypoxia-inducible factor-1α,HIF-1α)、过氧化物酶体增殖剂激活型受体γ(peroxisome proliferator-activated receptorγ,PPARγ)和突触相关蛋白25(synaptosomal-associated protein 25,SNAP25)等。本文综述了在排卵过程中PR如何调控卵泡破裂的分子机制,为相关排卵障碍性疾病的治疗提供重要的研究方向以及部分理论依据。
作者 宋翠淼 段彦苍 刘亚华 杜惠兰
机构地区 河北中医学院中西医结合生殖疾病协同创新中心河北省中西医结合肝肾病证重点实验室
出处 《生理科学进展》 CAS CSCD 北大核心 2018年第2期115-119,共5页 Progress in Physiological Sciences
基金 国家自然科学基金(81303002) 河北省自然科学基金(H2013206117) 河北省教育厅(ZD2015013)资助课题
关键词 孕激素受体 卵泡破裂 排卵 孕激素受体下游靶基因
分类号 Q492 [生物学—生理学]
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2018年 第2期

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