摘要
通过小鼠实验提出了一种亮白光LED联合古典音乐疗法。遭受过慢性不可预知性应激的小鼠被随机分成3组,均饲养在350 lx、光周期为12小时明亮12小时黑暗的环境中。对照组(C):不做任何处理。五行音乐组(M):每天播放2个小时古典音乐。五行音乐+光照组(M+B):每天播放2小时古典音乐并采用5 000 lx的白光LED照射。30天后用糖水偏爱度测试和强迫游泳实验来评估抑郁程度。与C组相比,M和M+B组的小鼠表现出更短的游泳不动时间和更长的游泳和攀爬时间(p<0.001)。M+B组小鼠的游泳不动时间(52.3±25.18 s)要短于M组(78.9±14.82 s),且差异存在统计学意义(t(9)=3.414,p=0.008<0.05)。亮白光LED联合古典音乐疗法能够提高应激小鼠的活力,具有一定的抗抑郁作用。
The treatment of bright white LED combined with classical music was proposed by laboratory mice.Mice suffered from chronic mild stress were divided randomly into three groups and exposed to 12:12 h bright light:dark(350 lx)conditions.The control group(C)received no treatment.The classical music group(M)was treated with classical music of 2 h per day.The classical music+bright light group(M+B)was treated daily with classical music of 2 h and 5 000 lx white LED light.Thirty days later,depression-like behaviors were assessed using saccharin solution preferences and forced swim tests.Mice in M and M+B demonstrated signi cantly shorter immobility times and longer climbing times and swimming times compared to those in C(p<0.001).It was observed that M+B experienced shorter immobility times(52.3±25.18 s)than M(78.9±14.82 s),and there was significant difference between two groups(t(9)=3.414,p=0.008<0.05).The combination therapy of bright white LED and classical music raised the vitality of mice and possessed antidepressant effect.
作者
王丹妮
代玉环
程静
张大伟
王成
庄松林
Wang Danni;Dai Yuhuan;Cheng Jing;Zhang Dawei;Wang Cheng;Zhuang Songlin(School of Optical-Electrical and Computer Engineer,University of Shanghai for Science and Technology, Shanghai 200093,China;Institute of Biomedical Optics and Optometry Optics,University of Shanghai for Science and Technology,Shanghai 200093,China)
出处
《红外与激光工程》
EI
CSCD
北大核心
2018年第4期261-266,共6页
Infrared and Laser Engineering
基金
国家重点研发计划(2016YFB1102300)
国家973项目(2015CB352001)
国家自然科学基金(61378060)
关键词
亮白光LED
古典乐
抑郁症
光周期
bright white LED
classical music
depression
photoperiod
