摘要
目的:研究奈达铂腔内灌注治疗非小细胞肺癌恶性胸腔积液的效果。方法:经病理确诊为肺癌恶性胸腔积液的患者共40例,分为2组。行胸腔穿刺术留置中心静脉导管引流排尽胸腔恶性积液后,治疗组20例,给予奈达铂胸腔灌注治疗,1次/周,每疗程1~2次,共1~4个疗程。对照组20例,引流积液后因患者拒绝化疗未予灌注药物治疗,部分予静脉或口服利尿剂治疗。结果:治疗组胸腔积液控制总有效率为75.0%,对照组为25.0%,差异有统计学意义(字2=10.00,P<0.05)。治疗组生活质量改善有效率为65.0%,对照组为10.0%,差异有统计学意义(字2=15.00,P<0.05)。结论:奈达铂腔内灌注治疗肺癌恶性胸腔积液疗效明显,改善患者生存质量。
Objective:To study the effect of endovascular infusion of Neidaplatin in the treatment of malignant pleural effusion of non-small cell lung cancer.Method:A total of 40 patients with malignant pleural effusion of lung cancer were divided into 2 groups.After drainage of malignant pleural effusion by indwelling central venous catheter through thoracic puncture,the treatment group(20 cases)was treated with Nedaplatin,once a week,twice per course of treatment,1 to 4 courses of treatment.The control group(20 cases)was treated with intravenous or oral diuretic because of the rejection of chemotherapy after drainage.Result:The response rate in treatment group was 75.0%,and control group was 25.0%,the difference was statistically significant(字2=10.00,P<0.05).The quality of life improvement rate in treatment group was 65.0%,and control group was 10.0%,the difference was statistically significant(字2=15.0,P<0.05).Conclusion:The treatmentof thoracic cavity perfusion with nedaplatin for pleural effusion with non-small-cell lung carcinoma has definite effect and also improve the quality of life.
作者
黄韵映
汪宝贞
HUANG Yunying;WANG Baozhen(The Second People’s Hospital of Foshan,Foshan 528000,China)
出处
《中外医学研究》
2018年第10期18-19,共2页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
非小细胞肺癌
恶性胸腔积液
奈达铂
Non-small-cell lung carcinoma
Malignant pleural effusion
Nedaplatin
