摘要
目的:观察不同外用药物治疗对带状疱疹皮损愈合的疗效。方法:387例带状疱疹患者随机分为三组,所有患者均予以静脉注射的基础治疗(更昔洛韦250 mg,1次/d)。喷昔洛韦组129例,皮损处予喷昔洛韦乳膏涂抹;干扰素组129例,皮损处予重组人干扰素α2b乳膏治疗;依沙吖啶+夫西地酸组129例,皮损处予乳酸依沙吖啶软膏和夫西地酸乳膏涂抹交替。观察并比较三组患者的皮损止疱时间、开始结痂时间、全部结痂时间、开始脱痂时间、全部脱痂时间、疼痛开始明显减轻时间和疼痛症状基本消失时间。记录皮损愈合情况并计算有效率及合并感染率。结果:三组止疱时间无明显差异,均在1d左右,但依沙吖啶+夫西地酸组较前两组开始结痂时间、全部结痂时间、开始脱痂时间和全部脱痂时间均明显减少(P<0.05),疼痛开始减轻和消失时间并无差异。依沙吖啶+夫西地酸组总有效率96.12%,显著高于喷昔洛韦组和干扰素组(83.72%和79.84%)(χ~2=5.4748,8.0843,P<0.05)。依沙吖啶+夫西地酸组合并感染率为0.78%,较喷昔洛韦组(11.63%)和干扰素组(13.18%)显著下降,表明依沙吖啶+夫西地酸组对于预防和控制皮损继发细菌感染的疗效显著高于喷昔洛韦组和干扰素组(χ~2=6.5300,7.6444,P<0.05)。结论:常规疗法联合外用依沙吖啶软膏和夫西地酸乳膏治疗带状疱疹皮损安全可靠,对于防止皮损化脓性感染及坏死,促进水疱干燥结痂,创面修复再生具有较好的疗效,能够显著提高皮损的临床治愈率。
Objective:To observe the skin healing clinical effects of different topical drugs in the treatment of herpes zoster.Methods:387 cases of herpes zoster were divided into 3 groups.All patient were administered with 250mg ganciclovir one time daily.Penciclovir group(n=129),Interferon group(n=129)and Ethacridine-Fusidic acid group(n=129)were painted at damaged place of skin respectively.Collected patients'clinical data including skin lesions blister time,the time of beginning to crust,all crusting time,the time of beginning to scab off time,all scabing off time,the time of pain began to relieve and of pain disappearance,and then record the number of lesions with suppurative infection or necrosis and calculate the rate of consolidation.Results:There was no significant difference on the time of skin lesions blister from three groups,the average time was one day.Crusting time and scabing off time of ethacridine-fusidic acid group was obviously less than other groups(P<0.05),while there was no difference in pain time.Ethacridine+fusidic acid group was 96.12%,significantly higher than that of penciclovir group and interferon group(83.72%and 79.84%)(χ2=2,5.4748,8.0843,P<0.05).Ethacridine+fusidic acid combination and the infection rate was 0.78%,compared with penciclovir group(11.63%)and interferon group(13.18%)significantly decreased,that of ethacridine+group for the prevention and control effect of fusidic acid lesions of secondary bacterial infection was significantly higher than that of penciclovir group and interferon group(χ2=6.5300,7.6444,P<0.05).Conclusion:Routine therapy combined with topical ethacridine cream and Fusidic Acid Cream for the treatment of herpes zoster lesions is safe and reliable,and it can prevent skin purulent infection and necrosis,helps dry the blister and promote the wound repair as well as the skin regeneration,it can significantly improve the clinical cure rate of skin lesions.
作者
周英丽
张少君
王渭玲
Zhou Yingli;Zhang Shaojun;Wang Weiling(Department of Dermatology,The First Affiliated Hospital of Xi’an Jiaotong University,Xi’an 710061)
出处
《陕西医学杂志》
CAS
2018年第5期653-655,共3页
Shaanxi Medical Journal
