摘要
目的分析耐多药肺结核患者既往治疗情况对治疗效果的影响。方法选择2015年1月~2017年5月我院收治的48例既往治疗过的耐多药肺结核患者的临床资料进行回顾性分析。入选病例均接受左氧氟沙星+丙硫异烟胺+对氨基水杨酸+丁胺卡那+乙胺丁醇或吡嗪酰胺的抗结核治疗,分析患者相关数据,评定既往治疗情况对临床治疗效果产生的影响。结果既往累计治疗次数≤2次、有二线药物治疗史、既往规律治疗患者的转阴率均显著高于累计治疗次数>2次、无二线药物治疗史、既往不规律的患者(P<0.05);累计治疗时间≤12个月患者的转阴率高于累计治疗时间13~24个月、>25个月的患者(P<0.05)。结论对二线药物使用情况进行规范,并对耐多药结核初治给予高度重视,合理调整用药方案。
Objective To analyze the effect of previous treatment of multidrug-resistant pulmonary tuberculosis patients on treatment outcome.Methods 48 cases of multidrug-resistant pulmonary tuberculosis treated in our hospital from January 2015 to May 2017 were retrospectively analyzed.The selected cases received anti tuberculosis treatment of levofloxacin+propanisoamine+p-amino salicylic acid+amikacin+ethambutol or pyloxacin,and analyzed the patient's data and assessed the effect of previous treatment on the effect of clinical treatment.Results The cumulative treatment times less than 2 times,the history of second line medicine treatment and the past regular therapy were significantly higher than the cumulative treatment times,2 times,no second line medication history,and previous irregular patients(P<0.05).The cumulative treatment time for patients with less than 12 months was higher than the cumulative treatment time of 13-24 months,>2.5 months of patients(P<0.05).Conclusion Standardize the use of second-line drugs,and attach great importance to the initial treatment of multidrug-resistant tuberculosis,and rationally adjust the drug use plan.
作者
李伟健
余肖兰
龙金环
赵玉英
张璇
刘冰
何妙玲
LI Weijian;YU Xiaolan;LONG Jinhuan;ZHAO Yuying;ZHANG Xuan;LIU Bing;HE Miaoling(Zhaoqing Tuberculosis Control Center,Zhaoqing 526020,China)
出处
《中国医药科学》
2018年第11期201-203,共3页
China Medicine And Pharmacy
关键词
肺结核
耐多药
影响因素
Previous treatment
Multidrug-resistant tuberculosis
Therapeutic effect
Effect
