摘要
目的探讨膳食维生素C摄入量与燃煤型氟中毒的关系。方法采用1∶1配对病例进行对照研究,在贵州省织金县招募200例氟中毒患者作为病例组和200例健康人作为对照组,通过面对面访谈的形式进行问卷调查。调查内容包括:对象一般社会人口因素和燃煤相关条件。采用含75个条目的食物频数问卷调查参与者既往1年的膳食摄入情况,采用logistic回归模型分析膳食维生素C摄入量与燃煤型氟中毒的相关性。结果校正混杂因素后,logistic回归分析发现膳食维生素C摄入量与燃煤型氟中毒呈负相关(P=0.001),与维生素C摄入量最低四分位组比较,第二至四分位组的OR值分别为0.28、0.21和0.06,95%置信区间分别为(0.08,0.89)、(0.05,0.81)和(0.01,0.31);将氟中毒分为氟斑牙和氟骨症敏感性分析发现,氟斑牙和氟骨症与膳食维生素C均呈负相关(P=0.013)。结论在一定范围内,膳食维生素C摄入量越多,燃煤型氟中毒危险性越低。除了改炉改灶等降低氟暴露水平外,应加强富含维生素C的新鲜蔬菜水果等食物的摄入,有利于燃煤型氟中毒的综合防治。
Objective To explore the relationship between dietary vitamin C intake and coal-burning fluorosis.Methods This 1∶1 matched case-control study,200 patients with fluorosis in zhijin county guizhou province recruitment as case group and 200 cases of healthy people as control group,through the questionnaire investigation in the form of face-to-face interviewed.The survey included general social and demographic factors and conditions related to coal burning.Using food frequency questionnaire containing 75 entries participanted before 1 year of dietary intake,dietary vitamin C intake and using logistic regression model analyzed the correlation of coal type fluorosis.Results After correction of confounding factors,logistic regression analysis showed that dietary vitamin C intake was negatively correlated with coalburning fluorosis(P=0.001),and the lowest four points of vitamin C intake were compared with second to four,OR values were 0.28,0.21 and 0.06 respectively,and 95%confidence interval(95%CI),respectively(0.08,0.89),(0.05,0.81)and(0.01,0.31)the sensitivity of fluorosis to fluorosis and skeletal fluorosis was analyzed.It was found that fluoride and bone fluorosis were negatively correlated with dietary vitamin C(P=0.013).Conclusion Within a certain range,the more intake of dietary vitamin C,the lower the risk of coalburning fluorosis.In addition to reducing the level of fluorine exposure,it is necessary to strengthen the intake of fresh vegetables and fruits rich in vitamin C,which is beneficial to the comprehensive prevention and control of fluorosis of coal type.
作者
刘俊
杨胜
罗明江
赵训
张元梅
陶娜
LIU Jun;YANG Sheng;LUO Mingjiang;ZHAO Xun;ZHANG Yuanmei;TAO Na(Preventive Medicine Teaching Center,School of Public Health,Zunyi Medical College,Zunyi,Guizhou 563006,China;Experimental Teaching Demonstration Center for Preventive Medicine of Gui.zhou Province,Zunyi,Guizhou 563006,China;Department of Pharmacy,Affiliated Hospital of Zunyi Medical College,Zun.yi,Guizhou 563006,China;Department of Chronic Disease,Center of Disease Control and Prevention of Zhijin County,Bijie,Guizhou 552100,China;Department of Cross Infection Control,the Fourth People's Hospital of ZunYi,Zunyi,Guizhou 563006,China)
出处
《现代医药卫生》
2018年第14期2119-2121,2124,共4页
Journal of Modern Medicine & Health
基金
国家自然科学基金资助项目(81460497)
遵义医学院博士启动基金项目(F-706)
关键词
例对照研究
抗坏血酸
氟化物中毒
煤/副作用
Case-control studies
Ascorbic acid
Fluoride poisoning
Coal/adverse effects
