摘要
目的:探讨宫颈上皮内瘤变(CIN)合并高危型人乳头瘤病毒(HR-HPV)感染患者阴道感染的变化。方法:收集合并HR-HPV感染病理确诊为CIN的患者共180例,设为研究组;并收集同期就诊检查提示宫颈细胞学无异常、HPV未感染的患者180例设为对照组。比较两组阴道感染状况的差异。结果:HR-HPV分型中HPV16亚型最常见。CIN合并HR-HPV感染患者感染细菌性阴道炎(BV)、需氧型阴道炎(AV)、滴虫性阴道炎(TV)、沙眼衣原体(CT)、混合感染、pH值>5的例数分别是73(37.8%)、23(12.8%)、36(20%)、45(25%)、20(11.1%)、46(25.6%),而对照组感染BV、AV、TV、CT、混合感染、pH值>5的例数分别是27(15%)、6(3.3%)、15(8.3%)、27(15%)、6(3.3%)、20(11.1%),差异具有统计学意义(P<0.05)。CIN合并HR-HPV感染患者感染外阴阴道假丝酵母菌病(VVC)的例数分别是18(10%),而正常对照组感染VVC的例数分别是16(8.9%),两组差异没有统计学意义(P>0.05)。结论:宫颈上皮内瘤变合并高危型人乳头瘤病毒感染患者阴道感染BV、AV、TV、CT、混合感染、pH值>5的例数有明显增加,宫颈上皮内瘤变合并高危型人乳头瘤病毒感染与其阴道感染存在联系。
Objective:To analyze the changes of vaginal infections in patients with cervical intraepithelial neoplasia and high-risk human papillomavirus infection.Methods:180 patients with cervical intraepithelial neoplasia combined with high-risk human papillomavirus infection were designed as study group.180 patients who with normal cervical cytology and negative HPV infectionwere designed as s control group.We compared the differences of vaginal infection in two groups.Results:HPV16 subtypes are most common in HR-HPV typing.Patients with CIN combined with HR-HPV infection infected with BV,AV,TV,CT,mixed infection,pH value>5 were73(37.8%),23(12.8%),36(20%)、45(25%),20(11.1%),46(25.6%),The control group infected with BV,AV,TV,CT,mixed infection,PH value>5 were 27(15%),6(3.3%),15(8.3%),27(15%),6(3.3%),20(11.1%),there were statistically significant differences.Patients with CIN combined with HR-HPV infection infected with VVC were 18(10%),The control group infected with VVC were 16(8.9%),there was no significant difference.Conclusion:Patients with cervical intraepithelial neoplasia combined with high-risk human papillomavirus infections BV,AV,TV,CT,mixed infection,pH value>5 had significant changes,cervical intraepithelial neoplasia combined with high-risk human papillomavirus infection is associated with vaginal infections.
作者
赵现立
高文丽
胡彤
高巧莲
杨晓花
Zhao Xianli;Gao Wenli;Hu Tong(Northwest Women and Children’s Hospital(Xi’an 710061))
出处
《陕西医学杂志》
CAS
2018年第8期997-999,1010,共4页
Shaanxi Medical Journal
关键词
宫颈上皮内瘤变
乳头状瘤病毒感染
阴道炎
Cervical intraepithelial neoplasia
Papillomavirus infections
Vaginitis
