摘要
目的了解赣南地区2013年~2016年临床分离的主要病原菌分布和多重耐药菌的流行变化。方法采用梅里埃Vitek2 compact对分离的菌株进行鉴定药敏。结果 4年内共分离41288株细菌,革兰阴性菌所占比例最高(67.00%)。病原菌分布中大肠埃希菌、鲍曼不动杆菌、铜绿假单胞菌、肺炎克雷伯菌、金黄色葡萄球菌位居前五。阿米卡星、哌拉西林/他唑巴坦对肠杆菌科细菌具有较高的的敏感性,鲍曼不动杆菌对多种常用抗菌药物呈现高水平耐药;铜绿假单胞菌对大部分抗菌药物较敏感,未检出万古霉素、利奈唑胺耐药的菌株。4年间耐甲氧西林金黄色葡萄球菌的检出均在25.00%以上;耐碳青霉烯肠杆菌科细菌的检出由2.90%上升至4.70%;耐碳青霉烯鲍曼不动杆菌的检出逐年下降。结论赣南地区CRE的检出不断上升,临床应根据药敏合理选用抗菌药物,采取有效防控措施减缓多重耐药菌的产生。
Objective To investigate the distribution of major pathogenic bacteria and the epidemic changes of multi-drug resistant bacteria in clinical isolates from 2013 to 2016 in south Jiangxi province.Methods Meridier Vitek 2 compact was used to identify the drug sensitivity of the isolates.Results In 4 years,41288 strains of bacteria were isolated,and Gram-negative bacteria accounted for the highest proportion(67.00%).Escherichia coli,Acinetobacter bauman,Pseudomonas aeruginosa,Klebsiella pneumoniae,and Staphylococcus aureus were the top five in the distribution of pathogenic bacteria.The sensitivity of Amikacin and piperacillin/tazobactam have higher of Enterobacteriaceae,Bauman acinetobacter to multiple antibiotics showed a high level of resistance;Pseudomonas aeruginosa to most sensitive antibacterial drugs,no detection of vancomycin and linezolid resistant strains.Over the past 4 years,the detection of methicillin-resistant Staphylococcus aureus was over 25.00%,and the detection of carbapenem Enterobacteriaceae increased from 2.90%to 4.70%.The detection of carbapenem resistant Acinetobacter bauman decreased year by year.Conclusion The detection of CRE is increasing in Gannan area.The rational use of antibiotics should be selected according to drug sensitivity,and effective prevention and control measures should be taken to slow down the production of multi drug resistant bacteria.
作者
张丽琴
刘婷
刘聪
邹淑慧
肖九长
ZHANG Li-qin;LIU Ting;LIU Cong;ZOU Shu-hui;XIAO Jiu-chang(Department of Laboratory,Ganzhou People's Hospital,Ganzhou 341000,Jiangxi,China)
出处
《医学信息》
2018年第5期123-124,共2页
Journal of Medical Information
基金
赣州市指导性科技计划(NO:GZ2016ZSF115)
关键词
临床病原菌
耐药性
多重耐药菌
Clinical pathogens
Drug resistance
Multi-drug resistant bacteria
