摘要
目的:分析《中华人民共和国卫生部药品标准·中药成方制剂》(以下简称《中药成方制剂》)中主治肝肾亏虚证的成方制剂用药规律。方法:收集主治肝肾亏虚证的所有成方制剂,运用中医传承辅助平台(V2.5)的关联规则分析等数据挖掘方法分析其用药规律,并比较3种高频疾病的用药异同。结果:主治肝肾亏虚证成方制剂共154首。其中涉及药物309种,高频药物有补血之熟地黄、生地黄、当归、白芍,补肝肾之何首乌、枸杞、女贞子、牛膝、菟丝子、五味子、杜仲,健脾益气之茯苓、黄芪、甘草、党参。核心药物组合以补肝肾(女贞子、墨旱莲、枸杞子、何首乌、牛膝)、养血(熟地黄、当归、白芍)和健脾之品(山药、茯苓)为主。涉及疾病67种,高频疾病为眩晕、耳鸣、不寐。治疗眩晕和耳鸣的药物组合基本相似,均以六味地黄丸、二至丸为基础加减,治疗不寐的药物组合以左归饮、二至丸为基础加减。结论:治疗肝肾亏虚证成方制剂以补肝肾、养血、健脾药物配伍为主,不同疾病肝肾亏虚证的用药很相似,但也有不同,体现了中医学异病同治,辨证与辨病相结合的治疗原则。本研究结果对指导临床实践及开发新药均有一定价值。
Objective:To analyze the medication rules of prescription in treating the Ganshen Kuixu deficiency(肝肾亏虚证).Methods:All of the TCM prescriptions of the Ganshen Kuixu deficiency were collected and their medication rules were analyzed using data mining methods of TCM Inheritance Support Platform(V2.5)for association regulation analysis etc.Results:There were a total of 154 prescriptions of the Ganshen Kuixu deficiency.There were a total of 309 medicines,among which high frequency medicines were prepared.There were a total of 67 diseases.Among them,high frequency diseases were vertigo,tinnitus and insomnia.Medicine combination for the treatment of vertigo and tinnitus were very similar,both of them were based on the Liuwei Dihuang pill(六味地黄丸)and Erzhi pill(二至丸).Medicine combination for the treatment of insomnia was based on the Zuogui decoction(左归饮)and Erzhi pill.Conclusion:The medicine combination of prescriptions of the Ganshen Kuixu deficiency were mainly for nourishing liver and kidney,nourishing blood and strengthening spleen drugs.The medication ofthe Ganshen Kuixu deficiency of different disease was very similar,but there were differences,too.The treatment principle of the combination of syndrome differentiation and disease differentiation was presented.This conclusion was valuable in directing clinical practice and developing new drugs.
出处
《中医临床研究》
2018年第15期99-102,共4页
Clinical Journal Of Chinese Medicine
基金
门氏中医流派的继承与创新山西省科技创新重点团队建设项目(201705D131021)
