摘要
氢溴酸右美沙芬是一种人工合成的右旋性吗啡喃衍生物,无耐药性且安全高效的中枢性镇咳药物,它能通过抑制延髓中枢而产生较强的镇咳作用。近年来随着氢溴酸右美沙芬在临床上广泛的应用,新剂型的研发也逐渐得到人们的重视,以期增加药物的生物利用度减少药物的毒副作用。本文对近十年以来的国内外关于氢溴酸右美沙芬剂型的研究文献进行综述,主要从速释制剂和缓释制剂两方面,为氢溴酸右美沙芬的剂型进一步开发利用提供参考。
Dextromethorphan hydrobromide is a synthetic dextral morphinan derivative,drug-resistant and safe and efficient central antitussive drugs,it can inhibit the medullary medullary and produce a strong antitussive effect.In recent years,with the rapid application of dextromethorphan hydrobromide in the clinical application of new formulations of research and development has gradually been people's attention,in order to increase the bioavailability of drugs to reduce drug side effects.In this paper,we reviewed the study literatures of dextromethorphan hydrobromide at home and abroad for the past ten years,and provided reference for the further development and utilization of the dosage form of dextromethorphan hydrobromide mainly from immediate release preparation and sustained release preparation.
作者
陈泳霖
信雪维
武建平
仲旗维
邹会峰
刘炳江
张文君
Chen Yonglin;Xin Xuewei;Wu Jianping;Zhong Qiwei;Zou Huifeng;Liu Bingjiang;Zhang Wenjun(School of Pharmacy,Harbin University of Commerce,Harbin 150076,China)
出处
《北方药学》
2018年第8期154-155,共2页
Journal of North Pharmacy
基金
省级大学生创新训练计划项目(项目号201710240039)
2017年哈尔滨市应用技术研究与开发项目(2017RAQXJ132)
黑龙江省应用技术研究与开发计划项目(GC13C106)
关键词
氢溴酸右美沙芬
剂型传输系统
止咳
研究进展
Dextromethorphan hydrobromide dosage form transmission system cough research progress
