摘要
评价偏碱性恩诺沙星注射液安全性,为临床安全用药提供理论依据。选择250只1日龄健康雏鸡,随机分为5组,分别为健康对照组和偏碱性恩诺沙星注射液1.75、5.25、8.75、17.5,mL/kg剂量组,每组50只连续给药3,d。停药7,d后,进行血液生理、生化指标测定和病理学组织观察,经与健康对照组相比,得出结论为偏碱性恩诺沙星注射液按临床推荐剂量1.75,mL/kg给药,临床应用安全。
This study is to evaluate the preclinical safety of alkali deviation type enrofloxacin injection to provide theoretical support for clinical safety drugs.250 1-day-old healthy chicks were randomly divided into 5 groups,the healthy group and other four groups,and given alkali deviation type enrofloxacin injection with different dosages(1.75,mL/kg,5.25,mL/kg,8.75,mL/kg and 17.5,mL/kg).50 chicks in the four groups were administered with alkali deviation type enrofloxacin injection by continuous perfusion for 3,days.After 7 days of drug withdrawal,the results were compared with that in the healthy group.It comes to the conclusion that the alkali deviation type enrofloxacin injection is safe in clinical at the recommended dose of 1.75,mL/kg.
作者
董惠峰
刘芳
张俊霞
李源
张凤洪
DONG Huifeng;LIU Fang;ZHANG Junxia;LI Yuan;ZHANG Fenghong(S&E Animal Pharmaceutical(Tianjin)Co.,Ltd.,Tianjin 300383,China;Enterprise Key Laboratory of Feed Microbial Preparation,Tianjin 300383,China)
出处
《天津科技》
2018年第7期35-38,共4页
Tianjin Science & Technology
关键词
偏碱性恩诺沙星注射液
雏鸡
安全性评价
alkali deviation type enrofloxacin injection
chick
safety evaluation
