摘要
目的比较不同冠状动脉病变的急性冠状动脉综合征(ACS)患者胆固醇和胆红素水平。方法回顾性分析2015年1月至2017年8月在首都医科大学附属北京友谊医院行冠状动脉造影和血管内超声(IVUS)的105例ACS患者的临床资料。根据最小管腔面积(MLA)将患者分为两组,冠状动脉病变程度较重组(重度组)(n=53):行IVUS时,左主干的MLA<6 mm2或左前降支(LAD)、左回旋支(LCX)、右冠状动脉(RCA)的MLA<4 mm2;冠状动脉病变程度较轻组(轻度组)(n=52):行IVUS时,左主干的MLA≥6 mm2或LAD、LCX、RCA的MLA≥4 mm2。比较两组患者总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、总胆红素(TBil)、直接胆红素(DBil)、间接胆红素(IBil)水平。结果重度组患者左主干和LAD、LCX、RCA的狭窄程度高于轻度组(P<0.01)。重度组患者TC和LDL-C高于轻度组[(4.74±1.07)mmol/L比(4.29±0.83)mmol/L,(2.71±0.74)mmol/L比(2.38±0.59)mmol/L],TBil和DBil低于轻度组[(11.93±3.82)mmol/L比(13.57±3.95)mmol/L,(3.17±1.05)mmol/L比(3.84±1.34)mmol/L](P<0.05)。结论对于ACS患者,联合检测胆固醇和胆红素可在一定程度上协助冠状动脉病变程度的评估。
Objective To compare cholesterol and bilirubin of acute coronary syndrome(ACS)patients with different severity of coronary artery lesions.Methods From Jan.2015 to Aug.2017,105 patients with ACS were analyzed retrospectively by coronaray arteriography and intravascular ultrasound(IVUS)in Beijing Friendship Hospital.According to the minimal lumen area(MLA),the patients were divided into two groups.Patients with MLA of left main less than 6 mm 2 or with MLA of left anterior descending(LAD),left circumflex(LCX)and right coronary artery(RCA)less than 4 mm 2,were divided into a severe group(n=53).Patients with MLA of loft main more than or equal to 6 mm 2 or with MLA of LAD,LCX and RCA more than or equal to 4 mm 2,were divided into a mild group(n=52).Total cholesterol(TC),high density lipoprotein-cholesterol(HDL-C),low density lipoprotein-cholesterol(LDL-C),total-bilirubin(TBil),direct-bilirubin(DBil)and indirect-bilirubin(IBil)were compared between the two groups.Results The degrees of stenosis of the left main artery and LAD,LCX,RCA in the severe group were higher than those in the mild group(P<0.01).TC and LDL-C in the severe group were higher than those in the mild group[(4.74±1.07)mmol/L vs(4.29±0.83)mmol/L,(2.71±0.74)mmol/L vs(2.38±0.59)mmol/L],TBil and DBil were lower than those in the mild group[(11.93±3.82)mmol/L vs(13.57±3.95)mmol/L,(3.17±1.05)mmol/L vs(3.84±1.34)mmol/L](P<0.05).Conclusion Detection both cholesterol and bilirubin were helpful to assess the severity of coronary artery lesions to some extent.
作者
刘思成
赵昱
陈晖
LIU Sicheng;ZHAO Yu;CHEN Hui(Department of Heart Center,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China;Karakqinqi Disease Prevention and Control Center,Chifeng 024400,China)
出处
《医学综述》
2018年第13期2517-2520,2525,共5页
Medical Recapitulate
关键词
冠状动脉造影
血管内超声
胆固醇
胆红素
Coronary arteriography
Intravascular ultrasound
Cholesterol
Bilirubin
