摘要
目的探讨黛力新联合雷贝拉唑治疗癔球症患者临床疗效及复发情况。方法选取该院2015-03~2017-03收治的癔球症患者63例,按照随机数字表法分为观察组32例和对照组31例。对照组采用雷贝拉唑治疗,观察组在对照组基础上联合黛力新治疗。两组疗程均为8周。比较两组临床疗效、治疗前后主要症状积分、焦虑和抑郁量表评分,以及随访6个月复发情况。结果观察组显效21例,有效10例,无效1例。对照组显效10例,有效7例,无效14例。观察组临床疗效优于对照组(P<0.01)。两组治疗后咽部不适、急躁易怒、食少纳呆评分降低(P<0.05),观察组治疗后评分低于对照组(P<0.01)。两组治疗后焦虑自评量表(SAS)和抑郁自评量表(SDS)评分降低(P<0.05),观察组治疗后评分低于对照组(P<0.01)。观察组随访6个月复发率(12.50%)低于对照组(41.94%)(P<0.05)。结论黛力新联合雷贝拉唑治疗癔球症患者临床疗效明显,可减轻焦虑和抑郁情绪,改善患者症状,降低复发率。
Objective To investigate the clinical efficacy of Deanxit combined with rabeprazole in treatment of glous hystericus and the follow-up relapsing rate.Methods 63 patients with glous hystericus were selected in our hospital from March 2015 to March 2017,and were randomly divided into the observation group(n=32)and the control group(n=31)according to random number table.The control group received rabeprazole.The observation group was treated with Deanxit plus rabeprazole.The two groups were treated for 8 weeks.The curative effect,the main symptom scores,the anxiety and depression scale scores,and the follow-up relapsing rate were compared between the two groups 6 months after treatment.Results In the observation group,the treatment result was markedly effective in 21 cases,effective in 10 and ineffective in 1 case.In the control group,the treatment result was markedly effective in 10 cases,effective in 7 and ineffective in 14 cases.The total effective rate of the observation group was higher than that of the control group(P<0.01).In both of the two groups,the scores of pharyngeal discomfort,irritability and anorexia after treatment were significantly lower than those before treatment(P<0.05),and the scores of the observation group after treatment were significantly lower than those of the control group(P<0.01).SAS and SDS scores were decreased in the two groups after treatment(P<0.05),and SAS and SDS scores of the observation group were significantly lower than those of the control group(P<0.01).The follow-up relapsing rate of the observation group 6 months after treatment(12.50%)was significantly lower than that of the control group(41.94%)(P<0.05).Conclusion Deanxit combined with rabeprazole is effective in treatment of glous hystericus.It can relieve anxiety and depression,improve the symptoms and reduce the recurrence rate in the patients.
作者
夏铭
张正坤
曾海龙
王伟
姚建华
杨惠
XIA Ming;ZHANG Zheng-kun;ZENG Hai-long(Department of Digestive Diseases,the People′s Hospital of Jiuquan City,Gansu 735000,China)
出处
《中国临床新医学》
2018年第7期676-679,共4页
CHINESE JOURNAL OF NEW CLINICAL MEDICINE
关键词
黛力新
雷贝拉唑
癔球症
疗效
复发
Deanxit
Rabeprazole
Glous hystericus
Curative effect
Recurrence
