摘要
目的 探究盐酸氨溴索联合阿奇霉素治疗小儿支气管肺炎的效果及其对中性粒细胞功能的影响。方法 选取2016年8月至2017年9月本院收治的支气管肺炎患儿94例作为研究对象,随机分为对照组(n=47,阿奇霉素治疗)和研究组(n=47,盐酸氨溴索联合阿奇霉素治疗),观察两组治疗效果、临床症状、中性粒细胞吞噬功能等指标。结果 研究组总有效率95.74%(45/47),对照组74.47%(35/47)(P<0.05)。研究组退热、呼吸通畅、咳嗽消失、肺啰音消失及X线片阴影消失时间分别为(2.84±0.58)d、(4.97±1.85)d、(6.23±2.22)d、(6.84±1.33)d及(5.77±1.74)d,对照组分别为(5.16±1.17)d、(7.32±2.08)d、(9.13±2.30)d、(9.04±1.97)d及(8.01±2.01)d。两组临床症状指标差异有统计学意义(均P<0.05)。治疗后,研究组中性粒细胞吞噬百分率、吞噬指数分别为(70.12±3.32)%、(1.57±0.12),对照组分别为(63.55±4.53)%、(1.38±0.15),两组中性粒细胞吞噬百分率、吞噬指数均明显升高(均P>0.05),研究组升高更加明显(均P<0.05)。研究组和对照组不良反应率分别为14.89%、10.64%,差异无统计学意义(P>0.05)。结论 盐酸氨溴索联合阿奇霉素治疗小儿支气管肺炎可有效缓解患儿临床症状,改善中性粒细胞吞噬功能,提高临床疗效,具有临床推广应用价值。
Objective To evaluate the clinical effect of ambroxol hydrochloric acid combined with azithromycin in the treatment of children with bronchopneumonia and the effect on neutrophil function.Methods 94 children with bronchopneumonia admitted into our hospital from August,2016 to September,2017 were selected as study objects and were randomly divided into a control group(n=45,azithromycin treatment)and a study group(n=45,ambroxol hydrochloride combined with azithromycin treatment).The treatment effects,clinical symptoms,neutrophil function,and other indicators in both groups were observed.Resμlts The total effective rate was 95.74%(45/47)in the study group and 74.47%(35/47)in the control group(P<0.05).The times for the disappearance of fever,respiratory patency,cough,lung rale,and X-ray shadow were(2.84±0.58)d,(4.97±1.85)d,(6.23±2.22)d,(6.84±1.33)d,and(5.77±1.74)d in the study group and were(5.16±1.17)d,(7.32±2.08)d,(9.13±2.30)d,(9.04±1.97)d,and(8.01±2.01)d in the control group,respectively,with statistical differences(all P<0.05).After the treatment,the percentage of neutrophil phagocytosis and the phagocytic index were(70.12±3.32)%and(1.57±0.12)in the study group and were(63.55±4.53)%and(1.38±0.15)in the control group.The percentage of neutrophil phagocytosis and phagocytosis index in the two groups increased significantly(P>0.05);and the increase in the study group was more obvious(P<0.05).The incidence of adverse reactions was 14.89%in the study group and was 10.64%in the control group(P>0.05).Conclusion Ambroxol hydrochloride acid combined with azithromycin in the treatment of children with bronchopneumonia can effectively relieve the clinical symptoms and improve neutrophil phagocytosis and clinical efficacy,so it is worth being clinically generalized.
作者
秦永平
Qin Yongping(People's Hospital of Tanghe County,Nanyang 473400,China)
出处
《国际医药卫生导报》
2018年第14期2158-2161,共4页
International Medicine and Health Guidance News
关键词
盐酸氨溴索
阿奇霉素
小儿支气管肺炎
中性粒细胞功能
Ambroxol hydrochloride acid
Azithromycin
Children with bronchopneumonia
Neutrophil function
