摘要
目的分析帕金森病(Parkinson’s disease,PD)患者幻觉的相关危险因素。方法选取河南科技大学第一附属医院神经内科门诊及住院的76例PD患者为研究对象,均完成非运动症状量表(non-motor symptoms scale,NMSS)、简易智力检查量表(mini-mental state examination,MMSE)和帕金森精神症状调查问卷(Parkinson psychosis questionnaire,PPQ)B类量表评分,使用ELISA方法检测研究组和对照组Hcy和CRP。对帕金森病精神症状的影响因素采用Logistic回归进行分析。结果23例PD患者出现幻觉,占30.1%。有幻觉的帕金森病患者年龄、病程、情绪评分及血清Hcy和CRP平均水平明显高于无幻觉的帕金森病患者,而MMSE评分则相反。Logistic回归分析发现,帕金森病的独立危险因素是年龄(OR=1.06,95%CI 1.03~1.25,P<0.05)和病程(OR=1.26,95%CI 1.18~1.79,P<0.05)。幻觉危险性随着Hcy和CRP的增加而增加,血清Hcy每增加1倍,幻觉的风险增加46%(OR=1.57,95%CI 1.15~2.21,P<0.05),CRP每增加1倍,幻觉危险性增加62%(OR=1.67,95%CI 1.12~2.13,P<0.05)。结论安抚情绪、改善智能状况以及对血清Hcy和CRP进行干预,可能有益于PD患者幻觉的治疗。
Objective To analyze the relationship between hallucinations and non motor symptoms and hyperhomocysteine and C reactive protein in patients with Parkinson's disease(PD).Methods 76 patients with PD were enrolled in the Department of Neurology of the First Affiliated Hospital of Henan University of Science and Technology.The non motor symptoms scale(NMSS),the Mini mental state examination(MMSE),the Parkinson psychosis questionnaire(PPQ)B were scored and analyzed,and Hcy and CRP were detected by ELISA in the study group and the control group.According to the results of PPQ-B,PD patients were grouped,PPQ-B≥1 was divided into hallucinations group,PPQ-B=0 was divided into non hallucinoid group.Logistic regression analysis was used to explore the influencing factors.Results In the patients with PD,23 patients(30%)had hallucinations.The levels of Hcy and CRP in the hallucinations group were higher than those in the non hallucinations group and the normal control group(P<0.05).The duration of the hallucinations and the MMSE were higher in the hallucinations group than in the non hallucinations group(P<0.05).Logistic regression analysis showed that age and course of disease were independent risk factors for hallucinations,with odds ratios(Odds Ratio,OR)of 1.06 95%CI:1.03 1.25,P<0.05)and 1.26(95%CI:1.18 1.79,P<0.05).The risk of hallucinations increased by 46%(OR=1.57,95%CI:1.15 2.21,P<0.05)when Hcy increases by 1 times,and the risk of hallucinations increased by 62%(OR=1.67,95%CI:1.12 2.13,P<0.05),when CRP increases by 1 time.Conclusion Easing sentiment,improving intelligence,and intervening serum Hcy and CRP may be beneficial for the treatment of hallucinations in the PD patients.
作者
闫俊强
乔靓
程丽妞
吴剑男
张育德
YAN Junqiang;QIAO Liang;CHENG Liniu;WU Jiannan;ZHANG Yude(Department of Neurology,the First Affiliated Hospital of Henan University of Science and Technology/Clinical Medical College,Henan University of Science and Technology,Luoyang 471000,China;Institute of Neurology,Henan University of Science and Technology,Luoyang 471000,China)
出处
《中国实用神经疾病杂志》
2018年第13期1460-1464,共5页
Chinese Journal of Practical Nervous Diseases
基金
国家自然科学基金(U1304809)
