摘要
目的观察月经周期不同阶段对乳腺肿瘤患者术后麻醉苏醒质量的影响。方法选取2015年6月~2016年6月于首都医科大学附属北京友谊医院行手术治疗的女性乳腺癌患者168例,根据患者手术当天所处月经周期的阶段,将受试者分为卵泡期组55例,排卵期组53例和黄体期组60例,观察并比较三组的苏醒质量,包括苏醒时间、警觉/镇静评分(OAA/S)、复苏后麻醉恢复室(PACU)停留时间及术后麻醉不良反应发生率。结果黄体期组苏醒时间和PACU停留时间短于卵泡期组和排卵期组,拔管后5、15及30 min OAA/S评分高于卵泡期组和排卵期组,差异均有统计学意义(P<0.05或P<0.01);排卵期组苏醒时间和PACU停留时间短于卵泡期组,拔管后5 min和15 min OAA/S评分高于卵泡期组,差异有高度统计学意义(P<0.01)。三组术后恶心呕吐发生率比较,差异有高度统计学意义(P<0.01);黄体期组恶心呕吐的发生率低于卵泡期组和排卵期组,差异有高度统计学意义(P<0.01)。结论在黄体期进行乳腺肿瘤手术的患者麻醉质量优于排卵期和卵泡期的患者,术后恶心呕吐的发生率也显著降低。
Objective To observe the influence of menstrual cycle on recovery quality in breast cancer patients undergoing radical mastectomy.Methods The 168 patients with breast cancer undergoing radical mastectomy from June 2015 to June 2016 in Beijing Friendship Hospital,Capital Medical University were selected,and all cases were divided into follicular phase group(n=55),ovulatory phase group(n=53)and luteal phase group(n=60)according to the different phases of menstrual cycle at the time of surgeries,and the recovery quality were observed and compared among three groups,including time of recovery,OAA/S score,time of stay in PACU and the incidence of postoperative anesthetic.Results The time of recovery and stay in PACU of the luteal phase group were shorter,and the modified observer′s assessment of alertness/sedation scale(OAA/S)score on 5,15 and 30 min were higher in follicular phase group than those in the ovulatory phase group and luteal phase group,the differences were statistically significant(P<0.05 or P<0.01).The time of recovery and stay in PACU were lower,OAA/S score on 5 min and 15 min were higher in ovulatory phase group than those in the follicular phase group,the differences were statistically significant(P<0.01).The incidence of postoperative nausea and vomiting was statistically significant among three groups(P<0.01),and the incidence of postoperative nausea and vomiting in luteal phase group were lower than those in follicular phase group and ovulatory phase group,the differences were statistically significant(P<0.01).Conclusion The patients undergoing breast cancer surgery during the luteal phase are better than those who are follicular phase and ovulatory phase,and the incidence of postoperative nausea and vomiting are also statistically reduced.
作者
朱欣艳
魏威
侯海军
ZHU Xinyan;WEI Wei;HOU Haijun(Department of Anesthesiology,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China)
出处
《中国医药导报》
CAS
2018年第22期103-106,共4页
China Medical Herald
关键词
月经周期
乳腺肿瘤
苏醒质量
Menstrual cycle
Breast cancer
Recovery quality
