摘要
目的探讨解毒化瘀Ⅱ方对乙型肝炎病毒(HBV)相关急性肝衰竭患者外周血Th17、Th1表达及临床疗效的影响。方法选择2013年2月~2016年3月在广西中医药大学第一附属医院、广西中医药大学附属瑞康医院、田东县中医院治疗的118例HBV相关急性肝衰竭患者作为研究对象,根据随机数字表分为对照组和观察组,每组各59例。对照组患者采用西医常规治疗,观察组患者采用解毒化瘀Ⅱ方+西医常规治疗。治疗8周后,对两组患者临床疗效、生化指标及外周血Th17及Th1表达水平进行评估。结果观察组总有效率显著高于对照组,差异有统计学意义(P<0.05)。治疗后,观察组患者谷草转氨酶、丙氨酸氨基转移酶和总胆红素均低于对照组,凝血酶原活动度高于对照组,差异有统计学意义(P<0.05)。治疗后,观察组患者Th17、Th1细胞亚群比例低于对照组,观察组患者Th1/Th17值高于对照组,差异有统计学意义(P<0.05)。结论解毒化瘀Ⅱ方可有效改善HBV相关急性肝衰竭患者肝功能,降低Th17及Th1表达水平,调节Th17/Th1,临床应用价值较高。
Objective To investigate the effects of Jiedu HuayuⅡDecoction on the expression of Th17 and Th1 in peripheral blood of patients with HBV related acute liver failure and its clinical efficacy.Methods From February 2013 to March 2016,118 patients with HBV related acute liver failure treated in the First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine,Rukang Hospital affiliated to Guangxi University of Traditional Chinese Medicine and Tiandong Hospital of Traditional Chinese Medicine were divided into control group and observation group according to random number table,with 59 cases in each group.The control group was treated with western medicine dialectical therapy,and the observation group were treated by Jiedu HuayuⅡDecoction and Western medicine dialectical therapy.After 8 weeks of treatment,the clinical efficacy,biochemical indexes and the expression levels of Th17 and Th1 in peripheral blood of two groups were evaluated.Results The total effective rate of the observation group was higher than that of the control group(P<0.05).After treatment,the AST,ALT and TBiL of the observation group were lower than those of the control group,and PTA was higher than that of the control group,with statistically significant difference(P<0.05).After treatment,the proportion of Th17 and Th1 cell in the observation group was lower than that of the control group,and the Th1/Th17 value of the observation group was higher than that of the control group,with statistically significant difference(P<0.05).Conclusion Jiedu HuayuⅡDecoction can effectively improve the liver function of patients with HBV related acute liver failure,decline the Th17 and Th1 expression,which has high clinical value.
作者
石清兰
毛德文
陈月桥
吕建林
SHI Qinglan;MAO Dewen;CHEN Yueqiao;LYU Jianlin(The First Ward of Department of Hepatopathy,the First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine,Guangxi Zhuang Autonomous Region,Nanning 530023,China)
出处
《中国医药导报》
CAS
2018年第21期122-125,共4页
China Medical Herald
基金
国家自然科学基金地区基金项目(81760849)
广西科学研究与技术开发计划重大课题(桂科攻1598011-7)
广西自然科学基金课题(2012GXNSFBA053102)
