摘要
以环丙基甲基酮和二甲氧基-N,N-二甲基甲胺为起始原料,依次通过羟醛缩合、与肼缩合成环、选择性甲基化反应和Vilsmeier-Hack反应得到目标产物3-环丙基-1-甲基-1H-吡唑-4-甲醛(化合物1),总收率高达48.0%。
Starting from cyclopropyl methyl acetone and dimethoxy-N,N-dimethyl methyl amine,the target compound of 3-cyclopropyl-1-methyl-1H-pyrazole-4-carboxaldehyde 1 was synthesized through 4 steps,successively through Aldol condensation,forming pyrazole ring by condensation with hydrazine,selective methylation reaction and Vilsmeier-Hack reaction,in a total yield of 48.0%.
作者
王先恒
赵长阔
袁智
曹颖
周亦琪
WANG Xian-heng;ZHAO Chang-kuo;YUAN Zhi;CAO Ying;ZHOU Yi-qi(School of Pharmacy,Zunyi Medical University,Zunyi,Guizhou 563099,China)
出处
《浙江化工》
CAS
2018年第8期20-23,共4页
Zhejiang Chemical Industry
基金
贵州省科技计划项目(黔科合SY[2015]3030)
遵义医学院招标课题([2013]F-680)
